Showing 45 results for Ranjbar
M Ranjbar, K Vahidshahi, M Mahmoudi,
Volume 16, Issue 56 (Jan 2007)
Abstract
Background and purpose: Evaluation is one of the most important bases of promoting the quality of education. It is very important to know the attendings’ and students’ viewpoints as evaluated and evaluator groups. So in this study the viewpoint of the attendings and students of School of Medicine of Mazandaran University of Medical Sciences (MUMS) about the students evaluation of the attendings, were studied.
Materials and Methods: In this descriptive-cross sectional study, all faculty members (FM) and students of the school of Medicine were included in the study by census sampling.
Data collection was done using a questionnaire including demographic questions and educational variables, the FM and students viewpoint about manner of evaluation (time, the way of distributing the forms and the explanation), the student's features in evaluation (awareness, truthfulness and puposes) and the instrument of evaluation (questionnaires and items).
Results: 345 individuals (95 FM and 250 students) took part in this study. The manner of evaluation (time, distribution and explanations) to most of FMs' and students’ opinion was appropriate. About student's awareness and truthfulness in filling in the questionnaires a considerable percentage of FMs (20-40%) had a negative opinion and over half of them had a negative attitude about the whole process of evaluation. About the items of theoretical, practical and clinical questionnaires, while the students laid stress on aspect such as: being a teacher and concepts transferring, on attendings opinion these aspects were less important.
Conclusion: To most FMs and students opinion, the manner of evaluation is appropriate but a considerable negative attitude exists among attendings about students’ awareness and truthfulness in filling in the questionnaire. The priorities of evaluation are different in these two groups’ point if view.
M Sabermoghadam Ranjbar, S.m Âlavinia,
Volume 20, Issue 76 (May 2010)
Abstract
Background and purpose: Penetrating eye injury is one of the most frequent trauma admitted in ophtalmological emergency rooms. The major concern when treating such a trauma is increased intra-ocular pressure and vitreous loss as a side effect of Succinylcholine and endotracheal intubation with no appropriate substitute drug available yet.
This study is aimed to determine whether the use of Propofol can prevent the increase intra-ocular pressure caused by succinylcholine injection and endotracheal intubation.
Materials and methods: 46 cases were selected and classified on the basis of Âmerican Society of Ânesthesiologists’ Physical Status Ï, ÏÏ (ÂSÂPS Ï, ÏÏ). Before induction of anaesthesia, intra-ocular pressure was measured for each individual case using Schiotz tonometer. Then, anaesthesia was carried out using Propofol (mean: 3mg/kg) and succinylcholine (mean: 1.2mg/kg) while endo-tracheal tube being placed in the trachea. Ïntra-ocular pressure was measured using the same method immediately and 2 minutes after intubation.
Repeated measurements test and correlation co-efficient was used to compare the mean difference and correlation between measurements. SPSS version 16 and SÂS-9.1 were used to conduct all statistical analysis.
Results: 33 patients, of them 13 female cases (39.4%) and 20 male (60.6%) cases have shown a mean intar-ocular pressure of 12 mmHg prior to induction. Âfter intubation, their immediate and two minutes intar-ocular pressure were 10.69 and 9.93 mmHg respectively.
Çonclusion: Ôur study shows not only the intra-ocular pressure is not raised but also it is decreased by rapid induction of Propofol followed by injection of succinylcholine and endotracheal intubation.
S.r Seyed Javadain, J Babashahi, M Ranjbar,
Volume 21, Issue 82 (May 2011)
Abstract
Background and purpose: The role of head nurses in delivering health care is important and training and making them physically and mentally (attitude and belief) ready to accept the role is also important, so the researchers aimed at identifying and explaining the factors influencing the formation and the maintenance of the nurses’ commitment to clinical nursing identity.
Materials and methods: The participants in this cross-sectional study were 123 male and female head nurses (based on Morgan Table) working in Mazandaran hospitals. The participants were randomly selected and were asked to fill in a questionnaire. For data analysis, Spearman correlation coefficient was used to measure the amount of correlation among variables and multiple regression analysis was employed to determine the variables related to commitment to clinical nursing identity.
Results: There was a significant positive relationship between “self-efficacy” and “attitudes toward the nurse to head nurse role transition” (r = 0.438), the same relationship was found between “social norms” and “attitudes toward the nurse to head nurse role transition” (r = 0.627). Ôn the other hand, there was no meaningful relationship between “attitudes toward the nurse to head nurse role transition” and “behavioral beliefs” (r = 0.437). Çontrary to the expectations, there was a positive relationship between “attitudes toward the nurse to head nurse role transition” and “commitment to clinical nursing identity”
(r = 0.369).
Çonclusion: Âccording to the aforementioned findings, nurses should be informed of the effectiveness of the managerial roles in the hospitals and in the clinical improvement of the patients so that the head nurses are provided with their colleagues’ support.
A Esmaeeli Nadimi, Gh.h Hassanshahi , V Tavakolian Ferdowsie, R Vazirinejad, A Abasi , H Zare Ranjbar ,
Volume 21, Issue 84 (Sep 2011)
Abstract
Background and purpose: Çardiovascular diseases are the most common causes of death in Ïran as well as in the world. SDF-1a, as an effective chemokine for decreasing inflammation and injury, plays a role in angiogenesis. This study compares and evaluates serum level of this chemokine in healthy people and those with ÂMÏ (Âcute Myocardial Ïnfarction) regarding age and gender.
Materials and methods: This case-control study was conducted on two groups: 63 patients and 63 healthy participants (the relatives of other patients in other wards). Blood samples were taken in the first 24h of admission in both groups, whereas in the case group another blood sample was taken in the seventh day after admission. Data were collected through taking history of the patients and Paraclinic. Serum level of SDF-1a was also measured in the participants.
Results: Âmong the participants enrolled in each group, 79.4% were males and 20.6% were females. Ïn the ÂMÏ group, 80.95% were admitted due to their first heart attack and 63.5% had Q wave MÏ at the time of discharge. There was no significant difference in the serum concentration of SDF-1a between control (33.58) and case (33.71) groups in the blood sample taken in the first 24 hours (p>0.05). However, a significant difference was observed between that of the first day blood sample taken from the control group and the seventh day sample of the case group (132.12, p<0.05).
Çonclusion: Ôur study showed that the concentration of SDF-1a increased during the first week after ÂMÏ. Therefore, SDF1-a can be effective in ÂMÏ as an anti inflammatory and angiogenetic chemokine.
A.r Khalilian, A Hamta, R Farhadi, H Ranjbaran,
Volume 21, Issue 86 (Feb 2012)
Abstract
Background and purpose: Since Low birth weight (LBW) is significantly related to infant mortality and it is one of the most important health indices at birth, this study was conducted to determine the most important factors affecting the low birth weight and their direct and indirect effects on response variable.
Materials and methods: To accomplish this analytical cross-sectional study, a checklist containing mother and infant’s demographic and pregnancy information was employed. Those with the weight of less than 2500g were considered as LBW infants. The information related to the next infant born with normal weight was also recorded. Overall, 466 pieces of information related to mothers and infants were recorded. Then, probable causal paths were theoretically drawn and path coefficients were calculated by LISREL 8.8.
Results: Path analysis revealed that the most effective factor on LBW was preterm delivery. The chance of LBW would incredibly increase with the occurrence of preterm delivery. The second important factor was pregnancy age and its negative path coefficient showed that the chance of LBW decreased with increase in the pregnancy age.
Conclusion: LBW chance can be controlled by accurate controlling of pregnancy and prevention of unnecessary pregnancy termination.
Ali Khavanin, Asghar Dehghani, Mohammad Ranjbarian, Mansour Rezazadeh Azari, Mohammad Sajad Emami Al Agha, Sara Azizian,
Volume 22, Issue 90 (July 2012)
Abstract
Background and purpose: Exposure to formaldehyde (FA), a highly-used chemical in industries, can induce serious health problems.Aim of this study was to explorethestatus of oxidant and antioxidant parameters in liver tissue of rats exposed to FAinhalation
Materials and methods: Twenty-one male albino Wistar rats divided into 3 separate groups randomly (n=7). Rats in groups 1 and 2 were respectively exposed to atmospheres containing6 and 12 PPM FA continuously (8 hours/day, 14 days), whileanimals in group 3 which served as control group were not exposed to any stress source.The animals were anesthetized by CO2 and after decapitation, liver samples were collected and processed for estimation of MDA and GSHlevels in the supernatant by spectrophotometric methodin control and exposed groups. Data were analyzed bynonparametric tests and significance was expressedas P<0.05.
Results: The present research findings showed statistically significant body weight loss in FA (12ppm) exposed group compared to the control and also FA (6ppm) exposed groups. However, a statistically significant decrease in liver weight and liver/body weight ratio was observed in the exposed groups compared to the control group (P<0.05). FA exposed groups showed a statistically significant decrease in GSH levelin liver tissue and statistically significant increase in MDA level in liver tissue (P<0.05). However, the levels of changes inbiochemical parametersin FA exposed groups were not dose-dependent.
Conclusion: The results of present study show that exposure to formaldehyde is toxic to liver tissue. Further research for exploring the toxicity of FA in occupationally exposed groups is recommended.
Ali Asghar Bayani, Mansour Ranjbar, Ali Bayani,
Volume 22, Issue 94 (12-2012)
Abstract
Background and purpose: Depression and social phobia are common psychiatric disorders. The main objective of this study was to study of relationship between social problem-solving and depression and social phobia among students.
Materials and methods: In this correlational- descriptive study, 403 (245female and 158 male) from Islamic Azad university, Azadshahr branch were selected through stratified random sampling method. In order to collect the data, were used The Social Problem-Solving Inventory-Revised (Short Form), Beck Depression Inventory, and Social Phobia Inventory. Data were analyzed through SPSS-13, Pearson's correlation, t test and analysis of Variance (AN0VA).
Results: Data analysis showed significant relationship between social problem solving ability and Social Phobia and depression (P<0.001). There was a significant difference among the students with low, medium and high social problem- solving ability. The students who had high ability in solving social problems had less depression and social phobia (P<0.001).
Conclusion: Social problem solving ability can decrease the depression and social phobia among university students. Teaching this skill will lead to promoting the level of mental health of university students.
Marzieh Ranjbaran, Mohammadreza Zolfaghari, Alireza Japoni-Nejad, Alireza Amouzandeh-Nobaveh, Hamid Abtahi, Mahsatabib Nejad, Ehsanallah Ghaznavi Rad,
Volume 23, Issue 105 (10-2013)
Abstract
Background and purpose: Due to the emergence of antibiotic resistance bacteria, treatment of urinary tract infection is becoming more problematic. Integrons are mobile genetic elements that play an important role in dissemination and accumulation of resistance genes of multidrug resistance in bacteria. The aim of the present study was to determine the antibiotic resistant profile, frequency of integron genes (Classes 1,2,3) and investigate the role of integrons in the development of antibiotic resistance among Escheria coli and Klebsiella pneumoniae isolated from urinary tract infections.
Material & methods: 50 E.coli and 50 K.pneumoniae isolated from the urine samples of patients who referred to Valiasr Hospital, Arak, Iran were subjected to this study. All the isolated samples were confirmed by standard biochemical tests. Isolates were tested for susceptibility to 16 antimicrobial drugs by using disk diffusion method and the distribution of different integron classes was determined by polymerase chain reaction (PCR).
Results: The highest rate of antibiotic resistance in K. pneumoniae isolates was found in rifampin (90%), erythromycin (90%), ceftriaxone (76%), amoxicillin-Clavulonic acid (76%), cotrimoxazole (70%), cefotaxime (70%) ceftazidime (66%) and for E.coli isolates in cotrimoxazole (88%), ceftriaxone (76%), amoxicillin-Clavulonic acid (74%), ceftazidime (72%) and cefotaxime (72%). All the E.coli isolates were susceptible to Imipenem, while only three (6%) of K.pneumoniae isolates were resistant to this antibiotic. Ninety percent of K.pneumoniae and 86% of E. coli isolates carried class 1 integrons, whereas class 2 integrons were found in 8% and 2% of E. coli and K.pneumoniae isolates, respectively. Class 3 integrons were not found.
Conclusion: The high frequency of Class 1 integron in E.coli and k. pneumoniae isolates associated with the high rate of antibiotic resistant indicate that may be integrons play an important role in facilitating the spread of antimicrobial resistance in this region.
Mansour Ranjbar, Ahmad Khaef Elahi, Hassan Danaee Fard, Aliasghar Fani,
Volume 23, Issue 109 (1-2014)
Abstract
Background and purpose: The role of health system managers has always been emphasized in the efficient running of system of hygienic and remedial services and much attention is paid to the selection of the best persons to do that. The main purpose of this study was to design the managers' competency model of health sector and evaluate them from the standpoint of middle managers of health system.
Material and methods: The study population included all the health system managers in Iran. The questionnaires were distributed among 385 people. The data were collected through the researcher's questionnaire which was used to assess the model proposed by applying library and field studies (interviewing with 30 person of health system managers of Iran). The questionnaire contains 8 main categories in competency criteria of managers and includes 63 questions. It was validated in terms of construct validity and Cronbach' alpha was used to ensure its internal consistency reliability. (more than 0.79 for each category). Inferential statistics (confirmatory factor analysis and structural equations model by specifying T-Value) and "LISREL" software was used to analyze the data collected from the questionnaire.
Results: 280 filled out questionnaires of the participants (75.1%) were analyzed in this study. Based on the collected data, T. values for knowledge of and professional awareness competencies, behavioral and intellectual, personal traits, service, responsibility, and considering the ideological and moral (ethical) values equal 11.90, 11.06, 8.39, 10.68, 6.55, 9.31, 3.43, and 2.17
Conclusion: Considering and applying the presented criteria in proposed competency model of health system managers which are ranked by the middle managers can be one of the way of improving the quality of management in the health system of Iran.
Tahereh Razi, Mohsen Shamsi, Mahboobeh Khorsandi, Nasrin Roozbahani, Mehdi Ranjbaran,
Volume 25, Issue 124 (5-2015)
Abstract
Background and purpose: There are many different studies indicating low knowledge of mothers about danger signs in sick children. This study aimed to assess the health belief model constructs about attention to danger signs in children less than five years old in Arak.
Materials and methods: A cross-sectional analytical study was carried out in 350 women with children less than 5 years old in Arak. Data was collected through structured interviews by a researcher made questionnaire that was developed according to the Health Belief Model and the checklist of mothers’ performance. It was then analyzed using Pearson correlation and linear regression.
Results: The mean scores for mothers’ behavior in paying attention to danger signs in their children, perceived susceptibility, severity, benefit, perceived barriers, cues to action, and self-efficacy were 51.53±42.03, 78.17±6.86, 81.56±7, 81.62±6.9, 69.42±8.28, 72.86± 8, and 73.62 ±7.5, respectively. Linear regression model showed that the respondents’ behavior improved by every one percent increase in the benefits and cues to action (0.18 and 0.21, respectively).
Conclusion: These findings suggest efficient training programs that could improve mothers’ behavior on paying attention to danger signs in their children.
Sayyadeh Nahid Mousavi, Mahbobeh Yaghobian, Mansour Ranjbar,
Volume 26, Issue 140 (9-2016)
Abstract
Background and purpose: Many studies investigated patient rights in Iran in the past decade, but there is few information on the awareness of cancer patients about their rights. This study was conducted to evaluate the awareness of hospitalized cancer patients about patient bill of rights.
Materials and methods: In a cross-sectional study 200 patients with cancer in oncology ward in Sari Imam Khomeini Hospital were recruited and face to face interviews were conducted (in 2014). Information was collected in a four-part survey questionnaire based on patient bill of rights. Data analysis was performed in SPSS10.
Results: The patients were 56.5% males and the mean age was 55.5±16.62 years. Among the patients 34% were illiterate and 17% were found to be with low literacy. The majority of the participants (79%) had not seen the patient bill of rights and 16% had low information about that. Also, most of the participants (98%) reported poor performance of the hospital staff in providing the patients with the contents of patient bill of rights at the time of registration and conditions and treatment costs at the time of admission. There were significant relationships between the scores for knowledge on patient bill of rights, educational level, occupation, and income.
Conclusion: In this study, the patients did not have enough information about their rights, therefore, appropriate planning is needed to increase awareness among patients about their rights.
Versa Omrani-Nava, Saeid Abediankenari, Jamshid Yazdani Charati, Yousef Yahyapour, Saeideh Sadat Shobeiri, Masoud Mohammadi, Hossein Ranjbaran, Siavash Abedi,
Volume 26, Issue 143 (12-2016)
Abstract
Background and purpose: HILA-G is an immunomodulatory molecule and alteration of its expression is prevalent during viral infections. HLA-G expression in HIV-positive patients has been inconsistent between different studies and some suggest that Interleukin-10 (IL-10) influences the expression of HLA-G. The aim of this research was to investigate the expression of IL-10 in HIV-positive patients and its relation with TCD4+ lymphocytes.
Materials and methods: In a case-control study, 20 HIV-positive patients, attending the Behavioral Consultation Center affiliated with Mazandaran University of Medical Sciences, were selected and 20 healthy volunteers were also enrolled. Expression of HLA-G was determined by Real-Time PCR. TCD4+ count and IL-10 concentration were evaluated by flow cytometry and ELISA, respectively.
Results: HLA-G gene expression was significantly different between the two groups (P<0.05). IL-10 concentration increased in patients and a revers relation was seen between TCD4+ cell count and IL-10 (r= -0.4, P= 0.1).
Conclusion: The results showed that the expression of HLA-G is deregulated during HIV infection and IL-10 could be considered as a biomarker of disease progression.
Fatemeh Ramezani Noroozani, Dorna Ojinejad, Ali Ghorbani Ranjbary,
Volume 26, Issue 144 (1-2017)
Abstract
Background and purpose: Nitrite is used for preserving food, especially in processed meat products. Processed foods containing nitrite are highly used in many countries. This harmful substances in water, soil and ecosystem endanger the health of people. In this study, we examined the effect of sodium nitrite on liver enzymes and histological structure of the liver in streptozotocin-induced diabetic rats.
Materials and methods: In this study, 60 adult male Wistar rats were divided into six groups (n= 10 per group): a control group, experimental groups receiving 175 and 350 mg/kg/day sodium nitrite, a diabetic control group, and diabetic groups receiving 175 and 350 mg/kg/day sodium nitrite for 60 days. Diabetes was induced in rats by intraperitoneal administration of streptozotocin (65 mg/kg). Blood samples were collected after anesthesia and the serum AST, ALP, and ALT were measured. Also, liver tissues were removed to investigate the histological changes. Statistical analysis was done by one way variation and student’s ANOVA Test. P values less than 0.05 were considered significant.
Results: The AST, ALP, and ALT levels significantly increased in diabetic groups and the group receiving 175 and 350 mg/kg sodium nitrite (P< 0.05). The mean levels of AST, ALP, and ALT levels in the diabetic group receiving 350 mg/kg sodium nitrite were 239 ± 3.8, 286 ± 3.5, 162 ± 3.6, respectively.
Conclusion: The results showed that sodium nitrite can induce adverse effects on the liver, especially on the liver in diabetic rats.
Nafiseh Seyed Zadeh Aghdam, Mina Chizari, Katayon Vakilian, Mehdi Ranjbaran,
Volume 26, Issue 144 (1-2017)
Abstract
Background and purpose: Sexual self-disclosure as a psychosocial sense is defined as individual’s interpretation on how to express feelings in marital relationships. This study aimed at determining the predictors of female sexual self-disclosure in Tehran.
Materials and methods: In this cross-sectional study, 200 married women in Tehran were selected by convenience sampling. Hurlbert Index of Sexual Desire and a demographic questionnaire were administered. Data was analyzed in SPSS V.20 applying descriptive and inferential statistics including Pearson, Spearman, ANOVA, and linear regression.
Results: The average score for sexual self-disclosure was 56.16±14.60. Some variables including the participant’s age, age of husband, duration of marriage, and time of last delivery were found to have significant inverse correlation with sexual self-disclosure. In multivariate model, marital life, the interest level in spouse, and duration of marriage were significant predictors of sexual self-disclosure.
Conclusion: Sexual self-disclosure was found to be low in this study. It is believed that marital life, duration of marriage, and interest level in spouse play important roles in women's sexual self-disclosure. Communication skills are suggested to be taught in premarital classes to enhance sexual self-disclosure, satisfaction and happiness in marriage.
Ghasem Abedi, Mahmood Moosazadeh, Mansour Ranjbar, Ehsan Abedini,
Volume 27, Issue 148 (5-2017)
Abstract
Background and purpose: Hospitals are needed to have enough readiness for apt reaction toward unexpected disasters, therefore, it is important to identify developed healthcare centers in different regions. This study aimed to investigate the developmental levels of educational hospitals for facing unexpected disasters in Mazandaran Province, Iran.
Materials and methods: In a cross-sectional study in Mazandaran educational hospitals in 2015, 56 individuals including the heads, chief managers and the officials for unexpected crisis were selected via purposive sampling. Data was collected using a researcher-made questionnaire consisting of 222 items. Data analysis was performed by numerical taxonomy.
Results: The participants were 88.5% males (n=23) and the mean age was 46.33±4.47 years. The educational level was Master in 5 (19%), while 21 (81%) hold a PhD degree. Results showed that Imam Khomeini hospital was relatively developed (0≤Fi≤0.5), Bu Ali, Fateme Zahra, Zare, Ayatollah Ruhani, and Amirkola pediatric hospitals were developing (0.5≤Fi≤0.7), and Razi and Shahid Beheshti hospitals were undeveloped (0.7≤Fi).
Conclusion: This study showed that most of the educational hospitals in Mazandaran Province are in inappropriate developmental state for facing the unexpected disasters. So, policy-makers must identify developed healthcare centers and enhance all medical centers for confronting the unexpected disasters.
Hossein Ranjbaran, Saeid Abediankenari, Mohammad Azadbakht, Alireza Khalilian, Marzei Momeninezhad Amiri, Seyed Saeed Hosseini, Atena Majidi,
Volume 27, Issue 153 (10-2017)
Abstract
Background and purpose: Today, increased rate of demand for insulin is predictable due to increasing cases of diabetics in the world. Therefore, it is necessary to develop economic approaches and increasing the production of insulin for the future and medicinal plants could be regarded as a promising prospect for insulin production.
Materials and methods: The Allium ursinum and Silybum marianum were collected. Each herbarium was identified in School of Pharmacy affiliated with Mazandaran University of Medical Sciences and the extract was used by percolation with 70% ethanol extraction, after the solvent was evaporated by using the rotary. After the successful isolation of mesenchymal stem cells (MSCs), Wharton's jelly was derived and approved. Then, the mesenchymal stem cells were differentiated to pancreatic beta cells with two herbal extracts.
Results: Compared with the control group, there was a significant difference between the levels of insulin in the culture medium obtained from the two plants (P= 0.0001). In addition, via specific dithizone staining, the insulin producing cells (IPCs) were proven.
Conclusion: The extracts of Allium ursinum and Silybum marianum were found capable in inducing differentiation of the mesenchymal stem cells derived from Wharton's jelly into IPCs. Allium ursinum was seen with the highest rate of insulin production, while Silybum marianum had the lowest rate of insulin production, therefore, Allium ursinum could be more effective in treatment of diabetes.
Forouzan Sadeghimahalli, Fattane Amuei, Mansour Ranjbar, Siavash Moradi, Hossein Khaleghzadeh-Ahangar,
Volume 28, Issue 167 (12-2018)
Abstract
Background and purpose: Internal evaluation is the systematic process of collecting and analyzing information to determine the benefits and disadvantages of a program and the extent to which its objectives are achieved. The aim of this study was to investigate the status of internal evaluation in clinical departments of Mazandaran University of Medical Sciences in two consecutive academic years.
Materials and methods: This descriptive cross-sectional study was performed in all clinical departments of Mazandaran University of Medical Sciences during 2015-2016 and 2016-2017. Data from eight domains of internal evaluation were collected using a checklist and some researcher-made questionnaires. Then, we studied the status of departments in eight domains of internal evaluation in relation to the standards and the status of all departments in two consecutive academic years. The evaluations for the years were compared and the dynamic trend was assessed. Data analysis was done applying descriptive statistics in SPSS.
Results: A good status of clinical departments was seen in most of the domains. Best performances within the two academic years studied were associated with courses, educational curriculum, and graduate affairs (74.53%, 78.66%, and 88.61%, respectively). Total scores for all clinical departments were 64.22% and 70.69% in 2015-2016 and 2016-2017, respectively.
Conclusion: Continuous internal evaluation reveals the strengths and weak points of the clinical departments. Therefore, more appropriate planning would be done and the departments could apply for further residency programs.
Tayebeh Ranjbarnejad, Fatemeh Ranjbarnejad, Massoud Saidijam,
Volume 28, Issue 169 (2-2019)
Abstract
Colorectal cancer (CRC) is one of the most common types of cancers worldwide. Despite the improved therapeutic and diagnostic strategies and screening programs, morbidity and mortality of CRC is still considerable. Currently, most common approaches for diagnosis of CRC are colonoscopy and fecal occult blood test (FOBT). Because of the invasive nature of colonoscopy and low sensitivity of FOBT, it is essential to find precise and noninvasive methods for early diagnosis, monitoring, and control of colorectal cancer. In recent years, there has been growing interest in finding sensitive and non-invasive molecular biomarkers by evaluating expression profiles of miRNAs in patients with colorectal cancer. Many studies have shown the important role of microRNAs in regulating the expression of genes involved in tumorigenesis, which has led researchers to evaluate their ability in diagnosis and treatment of various cancers such as colorectal cancer. In this regard, miR-21 was studied in many researches. miR-21 is one of the earliest identified cancer-promoting ‘oncomiRs’, targeting numerous tumor suppressor genes associated with proliferation, apoptosis, and invasion. Overexpression of miR-21 is observed in colorectal cancer and some other cancers. Recent studies have focused on the diagnostic and prognostic value of miR-21 and its implication in drug resistance of human cancers. The present study is a review of recent findings on the role of miR-21 in the regulation of target genes involved in colorectal carcinogenesis and its potential as a diagnostic and prognosis biomarker in this cancer.
Fahimeh Golbabaei, Mansoureh Jamshidimanesh, Hadi Ranjbar, Seyed Ali Azin, Sedighe Moradi,
Volume 29, Issue 172 (5-2019)
Abstract
Background and purpose: Women with Polycystic Ovarian Syndrome (PCOS) suffer from sexual dysfunction that is largely ignored in health clinics. This study was conducted to assess the efficacy of Permission, Limited Information, Specific Suggestion, Intensive Therapy (PLISSIT) model on sexual function of women with PCOS..
Materials and methods: This randomized clinical trial was performed in 66 women with PCOS aged 18-45 years old. They were divided into intervention and control groups (n=33 per group). Four weekly sessions of one hour individual counseling based on PLISSIT model were performed for the intervention group, while the control group received only routine care. Female Sexual Functioning Index questionnaire was completed at pre-test, and one month and three months after that in both groups. Data analysis was done applying Friedman, Mann–Whitney U, and Wilcoxon tests.
Results: There were homogeneity in subjects’ mean age (29.26±5.96), educational level (12.02±2.65) and BMI (25.95±3.67). Also, the two groups were similar in terms of symptoms including hirsutism, acne, alopecia, infertility and menstrual status. The mean scores for sexual functioning were 20.39±2.56, 24.40±4.70 and 23.73±1.26 at pre-test, after the intervention, and follow-up in intervention group, respectively (P<0.001), but no significant differences were seen between the scores of the control group (P=0.405).Also, the scores for lubrication were not significantly different between the two groups at post-intervention (P=0.245) and follow-up (P=0.423).
Conclusion: The PLISSIT model improved sexual functioning in women with PCOS, therefore, it could be recommended as an assessment and management tool in investigating sexual problems at early stages in this group of women.
(Clinical Trials Registry Number: IRCT201512023034N16)
Mahmood Moosazadeh, Ehsan Zaboli, Reza Alizadeh-Navaei, Hossein Ranjbaran, Omolbanin Amjadi, Manijeh Faghih, Motahareh Kheradmand, Zeinab Askari, Gholamali Godazandeh, Akbar Hedayatizadeh-Omran,
Volume 29, Issue 174 (7-2019)
Abstract
Background and purpose: The relationship between obesity and the risk of breast cancer has been highlighted in some studies. This research aimed at studying the association between anthropometric indices and breast cancer based on enrolment phase (cross-sectional phase) data in Tabari cohort study.
Materials and methods: In this cohort, 51 cases of breast cancer were recorded which were considered as the case group. Also, 153 individuals (without any type of cancer) from Tabari cohort population were randomly selected as control group. Data analysis was performed applying independent t-test, chi-square, and multivariate logistic regression.
Results: The frequency of waist circumference ≥88 cm in case group was slightly lower than that of the control group (74.5% vs. 75.2%, P= 0.926). In case group, the frequency of waist to hip ratio (less than 0.85) was lower than that of the control group (70.6% vs. 80.4%, P= 0.144). The risk of breast cancer was found to be higher in rural population (OR: 8.28, P<0.001) and in women with higher education (OR: 0.06, P<0.001).
Conclusion: This study did not confirm the association between anthropometric indices and breast cancer.