Langerhans cell histiocytosis (LCH) is a rare, proliferative disorder which is characterized by proliferation of pathological Langerhans cells within different organs. In 90% of cases the head and neck are affected. In this article, we report a 2.5-year-old boy with LCH who was referred to the pediatric department of Babol Dental School, with a chief complaint of fever, mucosal ulceration, gingival necrosis and tooth mobility. Our clinical diagnosis was Langerhans cell disease. In panoramic radiography, multiple well-defined radiolucencies were observed in both maxilla and mandible. Histopathological examination confirmed our diagnosis. The patient underwent chemotherapy with vinblastine for one year. Oral manifestations are common findings in LCH, therefore, dentist plays an important role in both diagnosis and management of this disease.

Multiple myeloma is a monoclonal malignant proliferation of plasma cells that causes osteolytic lesions in the vertebrae, ribs, pelvic bone, skull and jaw. We report a case of a 66 year-old-woman with pain and right facial swelling. Radiographic examination showed a well-defined radiolucent lesion in left posterior mandible. An incisional biopsy was performed and histopathological examination revealed proliferation of malignant plasma cell with off-center and hyper chrome nucleus. The results of biopsy, imaging, and laboratory investigations led to the diagnosis of multiple myeloma. This maxillofacial manifestation of multiple myeloma is not that rare, but dentist knowledge about maxillofacial manifestation can help in early diagnosis and consequently better prognosis of the disease.

Burkitt’s lymphoma (BL) is a poorly differentiated B-cell lymphoma. It is rare and in Africa as well as occurs most often in children and young adults. In general, BL includes about 1-2 % of all lymphomas in adults, especially those under 35 years of age, and it can be highly malignant and progressive. Herein, we report a 34-year-old woman with complains of toothache. Followed by drainage of mandibular abscess, soft tissue mass appeared in left mandible that was removed by surgical excision and histopathology report confirmed the diagnosis of BL. CT scan findings revealed involvement of abdominopelvic cavity organs, breast and orbital cavity. This type of tumor is very progressive, therefore, early detection and immediate treatment by accurate imaging could help to determine the extent of tumor.