Showing 5 results for Cinnamon
Maryam Azizkhani, Fahimeh Tooryan,
Volume 26, Issue 141 (10-2016)
Abstract
Background and purpose: Since long time ago herbal products and spices have been used as powders, essential oils (EOs), and extracts. They consist of antimicrobial components and could be applied as natural food preservatives. In the present work, the antiviral effect of cinnamon, rosemary, and zataria EOs has been investigated against norovirus surrogates including feline calicivirus (FCV) and murine norovirus (MNV).
Materials and methods: Different concentrations of EOs were individually mixed with each virus at titers of ca. 7-8 log TCID50/ml and incubated for 2 h at 4ºC and 37 ºC. The infectivity of the recovered viruses was evaluated by cell-culture assays.
Results: At 37 ºC, 3% of cinnamon, 2.5% of rosemary and 0.1% of zataria EOs decreased the FCV titers by 2. 38, 3.38, and 4.51 log TCID50/ml, respectively. At lower concentrations they were found to be less effective. Also, different concentrations of EOs decreased MNV titers by 0.25-1.44 log TCID50/ml. The maximum titer reduction (4.51 log TCID50/ml) was achieved when the FCV was treated at 37 ºC with 0.1% of zataria EO.
Conclusion: The reduction on the infectivity titers found for the tested norovirus surrogates with these EOs highlighted their potential role as biopreservatives to improve food hygiene and shelflife.
Azadeh Zahedifar, Mohammad Khodashenas, Bita Bijari, Fariba Zahedifar,
Volume 27, Issue 156 (1-2018)
Abstract
Background and purpose: Diabetes is a chronic disease which requires lifelong use of drugs. These drugs have high costs, therefore, there is a need to find economic, efficient, simple, and local solutions. This study aimed to investigate the effect of oral supplementation of cinnamon on glucose and glycosylated hemoglobin (HbA1c) levels in patients with type II diabetes.
Materials and methods: This clinical trial was conducted in 136 patients with type II diabetes in Birjand, Iran 2015. They were randomly assigned into intervention or placebo groups (n=68 per group). Subjects in the intervention group received 500 mg of cinnamon three times a day after breakfast, lunch, and dinner for 90 days (1500 mg daily). While the other group were advised to take the placebo in the same manner. Fasting blood sugar and HbA1c levels were measured before and after the study.
Results: In this study, the levels of HbA1c reduced significantly in intervention group after the treatment (P≤0.05). Daily intake of 1500 mg of cinnamon for 90 days was found to be effective in reducing glycosylated hemoglobin levels, but it did not have a significant effect on reducing fasting blood sugar in 90 days (P≥0.05).
Conclusion: Daily dose of 1500 mg of cinnamon for 90 days significantly reduced the HbA1C levels in type II diabetic patients and also had a moderate effect on fasting blood sugar concentrations. Therefore, it is recommended alongside conventional medication used in treatment of type II diabetes mellitus.
(Clinical Trials Registry Number: IRCT2016100230098N1)
Azam Nahvi, Hamid Reza Goli, Ali Davoodi, Abolfazl Hosseinnataj, Samira Sheydayee, Ali Jafari, Samaneh Hemmati,
Volume 32, Issue 217 (1-2023)
Abstract
Background and purpose: Garlic and cinnamon extracts, like fluoride varnish, play a role in caries control due to their antimicrobial effect and controlling demineralization. This analytical laboratory study was conducted in 2021 to investigate the antimicrobial effect of garlic and cinnamon extracts compared with fluoride varnish in controlling the infection of oral Lactobacillus acidophilus and Streptococcus mutans.
Materials and methods: The disk diffusion, minimum inhibitory concentration and the minimum bactericidal concentration tests were used to check the antimicrobial effect. Ampicillin and Erythromycin discs were used for positive control and sterile physiological serum was used for negative control. Data were analyzed using analysis of variance (ANOVA) and Bonferroni post hoc test.
Results: In disk diffusion test, cinnamon along with fluoride varnish (10.0±1.0mm) caused a significant increase in the diameter of the growth inhibition halo of L. acidophilus (P<0.001), However, the largest growth inhibition halo diameters in L. acidophilus and S. mutans were associated with garlic-cinnamon-varnish (12.0±1.58mm) and fluoride varnish (9.0±0.71mm), respectively. In both strains, the antimicrobial effect of garlic extract was significantly lower than other compounds (P<0.001). The most inhibitory and bactericidal effects were associated with fluoride varnish seen in S. mutans.
Conclusion: According to this study, cinnamon and fluoride varnish has a synergistic antimicrobial effect against L. acidophilus in laboratory conditions. Also, cinnamon extract due to similar effects to fluoride varnish, can be useful as an alternative agent in controlling and preventing dental caries.
Elham Hadipour, Seyedeh Shirin Shahangian, Elham Ramazani, Dr Zahra Salmasi,
Volume 33, Issue 219 (4-2023)
Abstract
Background and purpose: Metabolic syndrome refers to a set of diseases including insulin resistance, high blood glucose levels, obesity, high blood pressure, and dyslipidemia. The cinnamon plant is a member of the Lauraceae family and is considered a universal medicinal plant. Traditional medicine studies reported the therapeutic effects of this plant in the reduction of blood glucose levels, blood pressure, obesity, and improving dyslipidemia. The present study aimed to review the effect of cinnamon and its active compounds on metabolic syndrome.
Materials and methods: The search was carried out in Science Direct, Google Scholar, Pub Med, Scopus, and SID using the following keywords: cinnamon, cinnamaldehyde, obesity, high blood pressure, diabetes, and blood lipid profiles. Relevant articles published in May 2007 to September 2022 were selected.
Results: Data obtained from different studies (clinical studies, in vivo) on the effects of cinnamon and its active ingredients showed the protective effects of this plant in metabolic syndrome in different ways.
Conclusion: Cinnamon could decrease the rate of complications and mortality caused by metabolic syndrome.
Reza Valizadeh, Hamidreza Mohammadi, Ali Ghaffarian Bahraman, Mohsen Mohammadi, Javad Ghasemian Yadegari,
Volume 33, Issue 221 (5-2023)
Abstract
Background and purpose: Acute liver failure is caused by several factors including drugs. Isoniazid, which is used as an effective drug in treatment of tuberculosis, is considered a strong toxic agent for the liver. The purpose of this study was to investigate the effects of cinnamon extract on isoniazid-induced hepatotoxicity in rats.
Materials and methods: In this experimental study, 60 male Wistar rats were randomly divided into six groups. Liver damage and oxidative stress were induced by administration of isoniazid (300 mg/kg/day) for 14 consecutive days. Different doses of cinnamon extract (50, 100, and 200 mg/kg) were administered by gavage. Liver damage caused by isoniazid was evaluated by examining serum biochemical factors, amount of reactive oxygen species, glutathione, antioxidant capacity, lipid peroxidation, and histopathological changes in liver tissue. Data analysis was performed in Prism software applying one-way analysis of variance (ANOVA) and Tukey's post hoc test.
Results: Isoniazid at 200 mg/kg caused liver damage and significantly increased liver damage biomarkers (biochemical biomarkers, oxidative stress indices, and histopathological changes) (P<0.05). On the other hand, different doses of cinnamon extract significantly reduced the biomarkers of liver damage caused by isoniazid (P<0.05) and also improved the histopathological changes of liver tissue.
Conclusion: Cinnamon extract with antioxidant properties protects the liver against oxidative damage caused by isoniazid.
