Volume 32, Issue 214 (11-2022)                   J Mazandaran Univ Med Sci 2022, 32(214): 113-123 | Back to browse issues page

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Esmaeili M, Yousefinia Pasha G, Alijanpour E, Hamidian M T, Ezoji K, Seyfi S. Comparing the Efficiency of Propofol-Ketamine Combination and Propofol-Fentanyl on Recovery Time in Colonoscopy: A Double Blind Randomized Controlled Clinical Trial. J Mazandaran Univ Med Sci 2022; 32 (214) :113-123
URL: http://jmums.mazums.ac.ir/article-1-15966-en.html
Abstract:   (628 Views)
 Background and purpose: Appropriate drug regimen during colonoscopy is one of the matters of concern in anesthesia. This study was conducted to compare the efficacy of propofol-ketamine combination and propofol-fentanyl in colonoscopy.
Materials and methods: In a single-blind randomized clinical trial, 200 patients aged 18-60 years candidate for colonoscopy, were randomly allocated into two groups to receive either fentanyl-propofol (PF) or ketamine-propofol (PK) using block randomization. Recovery time (end of injection until Steward Score was 6) as the primary outcome and vital signs, complications, total dose of propofol, and satisfaction of the doctor performing the colonoscopy as secondary consequence were compared between the two groups.
Results: Recovery time was 2.97 ± 0.89 min in the fentanyl-propofol group and 8.84 ± 1.73 min in ketamine-propofol group (P<0.001). Systolic and diastolic blood pressure and heart rate significantly decreased in the fentanyl-propofol group compared with the other group (P <0.001) which was persistent until five minutes after colonoscopy. Restlessness was seen in 28 patients receiving propofol-ketamine but no patient in fentanyl-propofol group developed this condition (P <0.001). Satisfaction of the doctor performing the colonoscopy and propofol dose were significantly better in patients that received ketamine-propofol (P<0.05).
Conclusion: Fentanyl-propofol combination was associated with faster recovery time and less restlessness than the ketamine-propofol compound, but the latter combination is recommended as it led to better hemodynamic stability, greater satisfaction of the doctor, and reduced dose of propofol.

 (Clinical Trials Registry Number: IRCT20190529043750N1)
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Type of Study: Research(Original) | Subject: anesthesia

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