Volume 31, Issue 200 (9-2021)
J Mazandaran Univ Med Sci 2021, 31(200): 199-214 |
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Farzipour S, Talebpour Amiri F, Alvandi M, Shaghaghi Z, Yazdi A. Ferroptosis in Cardiovascular Disease: Basic Mechanisms and Implications for Cardiovascular Disease. J Mazandaran Univ Med Sci 2021; 31 (200) :199-214
URL: http://jmums.mazums.ac.ir/article-1-16906-en.html
URL: http://jmums.mazums.ac.ir/article-1-16906-en.html
Abstract: (1495 Views)
Ferroptosis is a new type of programmed cell death that plays an important role in various cardiovascular diseases, such as myocardial infarction, reperfusion injury, and heart failure. Cardiomyocyte loss is the most important determinant of morbidity and mortality, so, it is crucial to fully understand the regulatory mechanisms of ferroptosis signaling. In fact, inhibition of cardiac ferroptosis is a promising therapeutic strategy for cardiovascular diseases. However, the biological and pathological contexts in which ferroptosis might operate are poorly defined. Herein we discuss the role of ferroptosis in various cardiovascular diseases, provide an update on current knowledge about the molecular mechanisms that govern ferroptosis, and discuss about the role of ferroptosis inhibitors in control of ferroptosis induced cardiovascular disease in animal models.
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