Materials and methods: In a randomized controlled clinical trial, 28 patients with oral lichen planus were selected sequentially and were randomly divided into an intervention group and a placebo group (n= 14 per group). Patients in intervention group received topical corticosteroid, antifungal medication, and one Sina Curcumin capsule for a month. In placebo group, the patients were given corticosteroid, antifungal medication, and one placebo capsule for the same duration.

Results: There were significant differences in appearance of lesions and pain before treatment (P=0.227 and P=0.769, respectively), two weeks after treatment (P=0.031 and P= 0.0497), and four weeks after treatment (P=0.0001 and P= 0.019). Lesion size did not show significant differences between the two groups before (P=0.349), two weeks after (P=0.213), and four weeks after treatment (P=0.123).