Volume 33, Issue 1 (11-2023)
J Mazandaran Univ Med Sci 2023, 33(1): 295-301 |
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Maghsoodi A, Azadbakht M, Godazandeh G, Akbari F, Nodehi A, Mollaei A. A Separate Evaluation of Echium Amoenum L. and Viola Odorata L. Extracts on Solving Gall Stones. J Mazandaran Univ Med Sci 2023; 33 (1) :295-301
URL: http://jmums.mazums.ac.ir/article-1-18494-en.html
URL: http://jmums.mazums.ac.ir/article-1-18494-en.html
Ali Maghsoodi 
, Mohammad Azadbakht , Gholamali Godazandeh , Fatemeh Akbari , Abbas Nodehi , Aghil Mollaei
, Mohammad Azadbakht , Gholamali Godazandeh , Fatemeh Akbari , Abbas Nodehi , Aghil Mollaei
Abstract: (405 Views)
Materials and methods: At first, gallstones were collected and the stone compounds were identified by UV and DSC. Gallstones are divided into equal parts in terms of size and weight (200 mg). Three acidic, alkaline and distilled water media were prepared as a control group along with the experimental groups which contained Echium amoenum and viola odorata extracts with concentrations of 1 mg/ml, 10 mg/ml, 100 mg/ml and 500 mg/ml, respectively. A gallstone sample was placed in it and sampled after 24 and 48 hours and the dissolution rate of the stone compounds was measured by an auto-analyzer.
Results: The UV spectrum showed the presence of bilirubin in the gallstones and the DSC thermogram showed the presence of cholesterol in the stones. Examination of isolated gallstone compounds showed Echium extract with a concentration of 500 mg was able to dissolve 70% of the calcium and the Viola extract with a concentration of 500 mg has been able to dissolve 50% of the cholesterol and 80% of the stone’s calcium.
Conclusion: Echium amoenum and Viola odorata have a significant effect on the dissolution of gallstones (P<0.0001).
Type of Study: Brief Report |
Subject:
Pharmacognosy
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