Volume 32, Issue 217 (1-2023)
J Mazandaran Univ Med Sci 2023, 32(217): 124-134 |
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Davoudi A, Azadeh S, Najafi N, Soleimanpourian B, Alishahi A, Mokhtariani A, et al . Comparative Study on the Role of Serum Levels of Interleukin-6 and Interleukin-8 in Predicting the Severity of COVID-19 and Prognosis in Patients Admitted to Ghaemshahr Razi Hospital. J Mazandaran Univ Med Sci 2023; 32 (217) :124-134
URL: http://jmums.mazums.ac.ir/article-1-18926-en.html
URL: http://jmums.mazums.ac.ir/article-1-18926-en.html
Alireza Davoudi 
, Sahar Azadeh , Narges Najafi , Bahareh Soleimanpourian , Abbas Alishahi , Armaghan Mokhtariani , Mazaher Azordeh , Reyhaneh Shojaei-Asrami , Mohammad Khademloo , Leila Delavarian , Fatemeh Ahangarkani
, Sahar Azadeh , Narges Najafi , Bahareh Soleimanpourian , Abbas Alishahi , Armaghan Mokhtariani , Mazaher Azordeh , Reyhaneh Shojaei-Asrami , Mohammad Khademloo , Leila Delavarian , Fatemeh Ahangarkani
Abstract: (782 Views)
Background and purpose: The Coronavirus Disease 2019 (COVID-19) pandemic, caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in a worldwide emergency. Various studies show conflicting and diverse results on the role of inflammatory cytokines in predicting the severity and prognosis in patients with COVID-19. The aim of this study was to compare the serum levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) in predicting the severity of COVID-19 and prognosis in patients admitted to Qaemshahr Razi Hospital.
Materials and methods: In this cross-sectional prospective study, the serum levels of interleukin 8 and 6 were measured in 51 patients with COVID-19 and compared with 25 healthy individuals in Qaemshahr Razi Hospital, 2021. ELISA method was used to measure these cytokines and data analysis was performed in SPSS V25.
Results: The serum levels of IL6 and IL8 in the patient group were about 4 times and 6 times higher than those of the control group, respectively. Average levels of IL-6 (P=0.004) and IL-8 (P<0.001) were significantly higher in patients with severe COVID-19 compared to moderate form and control group. There was no correlation between the duration of hospitalization and the level of IL-6 (P=0.1), while there was a significant correlation between the length of hospital stay and the level of IL-8 (P=0.012).
Conclusion: IL-6 and IL-8 serum levels in patients with COVID-19 can be helpful in predicting the severity of disease and prognosis of patients.
Materials and methods: In this cross-sectional prospective study, the serum levels of interleukin 8 and 6 were measured in 51 patients with COVID-19 and compared with 25 healthy individuals in Qaemshahr Razi Hospital, 2021. ELISA method was used to measure these cytokines and data analysis was performed in SPSS V25.
Results: The serum levels of IL6 and IL8 in the patient group were about 4 times and 6 times higher than those of the control group, respectively. Average levels of IL-6 (P=0.004) and IL-8 (P<0.001) were significantly higher in patients with severe COVID-19 compared to moderate form and control group. There was no correlation between the duration of hospitalization and the level of IL-6 (P=0.1), while there was a significant correlation between the length of hospital stay and the level of IL-8 (P=0.012).
Conclusion: IL-6 and IL-8 serum levels in patients with COVID-19 can be helpful in predicting the severity of disease and prognosis of patients.
Type of Study: Research(Original) |
Subject:
infection
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