Volume 33, Issue 1 (11-2023)
J Mazandaran Univ Med Sci 2023, 33(1): 287-294 |
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Mohammad Hosseini Nezhad A S, Ortegoli Z, Malekshahi fard N, Baazm M. Effect of Resveratrol on Hippocampal Injury Induced by Trimethyltin Chloride in Rats. J Mazandaran Univ Med Sci 2023; 33 (1) :287-294
URL: http://jmums.mazums.ac.ir/article-1-19803-en.html
URL: http://jmums.mazums.ac.ir/article-1-19803-en.html
Abstract: (651 Views)
Background and purpose: Trimethyltin chloride (TMT) is an organotin thermal stabilizer used in plastics manufacture, and has strong neurotoxicity, especially on the hippocampus. The aim of this study was to investigate the effects of resveratrol, an antioxidant, in reducing the side effects of TMT on the hippocampus.
Materials and methods: In this experimental study, 48 male Wistar rats were randomly divided into four groups: control, TMT (8 mg/kg, single dose), ethanol, and resveratrol (30 mg/kg). Animals received six days of treatment with resveratrol. At the end of the treatment period, the spatial, working, and reference memories were investigated using a radial arm maze. Histological evaluation and the expression of Bax and Bcl2 were analyzed in the hippocampus.
Results: According to our findings, TMT damaged spatial, working, and reference memories. The number of pyknotic cells and the expression of Bax significantly increased (P˂0.05) while the expression of Bcl2 decreased (P˂0.05). In addition, resveratrol could improve these negative effects of TMT on the hippocampus (P˂0.05).
Conclusion: Resveratrol may prevent damages caused by TMT in the hippocampus of rat. Resveratrol might be a candidate for use as an adjunct therapy against the neurotoxicity of TMT.
Materials and methods: In this experimental study, 48 male Wistar rats were randomly divided into four groups: control, TMT (8 mg/kg, single dose), ethanol, and resveratrol (30 mg/kg). Animals received six days of treatment with resveratrol. At the end of the treatment period, the spatial, working, and reference memories were investigated using a radial arm maze. Histological evaluation and the expression of Bax and Bcl2 were analyzed in the hippocampus.
Results: According to our findings, TMT damaged spatial, working, and reference memories. The number of pyknotic cells and the expression of Bax significantly increased (P˂0.05) while the expression of Bcl2 decreased (P˂0.05). In addition, resveratrol could improve these negative effects of TMT on the hippocampus (P˂0.05).
Conclusion: Resveratrol may prevent damages caused by TMT in the hippocampus of rat. Resveratrol might be a candidate for use as an adjunct therapy against the neurotoxicity of TMT.
Type of Study: Brief Report |
Subject:
anatomy
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