Volume 33, Issue 229 (1-2024)                   J Mazandaran Univ Med Sci 2024, 33(229): 93-105 | Back to browse issues page

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Iraei R, Khanicheragh P, Musavi H, Yazdi M, Chavoshinejad N, Yazdian-robati R. Natural Compounds Activating the AMPK/SIRT1pathway a Therapeutic Potential for Non-Alcoholic Fatty Liver Disease. J Mazandaran Univ Med Sci 2024; 33 (229) :93-105
URL: http://jmums.mazums.ac.ir/article-1-19999-en.html
Abstract:   (293 Views)

Lipid accumulation in the liver is associated with non-alcoholic fatty liver disease (NAFLD), with obesity and insulin resistance being the main contributing factors. The AMPK/SIRT1 signaling pathway plays a crucial role in addressing lipid metabolism issues. Recent studies have demonstrated that the AMPK/SIRT1 signaling axis is involved in preventing and reducing liver damage. Upregulation of AMPK/SIRT1 can regulate lipid metabolism and oxidation in liver cells. In NAFLD, increased activity of AMPK/SIRT1 can inhibit the synthesis of fatty acids and cholesterol by down-regulating adipogenesis genes (FAS, SREBP-1c, ACC, and HMGCR). Therefore, activation of the AMPK/SIRT1 signaling pathway represents a potential therapeutic target for liver disorders. This review summarizes the most recent studies on the AMPK/SIRT1 pathway signaling axis and the mechanisms of herbal activators of the AMPK/SIRT1 pathway in non-alcoholic fatty liver
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Type of Study: Review | Subject: Nano technology

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