Volume 33, Issue 227 (12-2023)                   J Mazandaran Univ Med Sci 2023, 33(227): 153-158 | Back to browse issues page

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asaeian H, shoja shafiee F, Aghajani B, lashtoo Aghaee B. Investigating the Level of Lung Involvement by CT scans in Covid-19 Patients and its Relationship with the Level of Blood Biomarkers: A Retrospective Study. J Mazandaran Univ Med Sci 2023; 33 (227) :153-158
URL: http://jmums.mazums.ac.ir/article-1-20014-en.html
Abstract:   (334 Views)
Background and purpose: Coronavirus disease 2019 (COVID-19) is a multi-organ illness characterized by significant involvement of the coagulation cascade, immune response, and inflammation. This investigation aimed to explore the significance of various biomarkers, such as interleukin 6 (IL-6), lactate dehydrogenase (LDH), D-dimer, and N-terminal prohormone of brain natriuretic peptide (NT-proBNP), concerning lung complications in COVID-19 patients.
Materials and methods: This retrospective study was conducted at Imam-Sajjad Hospital in Ramsar, Mazandaran, from May to August 2021 and focused on all COVID-19 patients with lung involvement who were admitted. An experienced radiologist assessed each patient's computed tomography (CT) scans and assigned a lung involvement score ranging from zero to 10 for each lung. These scores were categorized as mild (0-10), moderate (10-15), or severe (15-20). In addition to demographic data, serum levels of IL-6, LDH, D-dimer, and NT-proBNP were obtained from patient records, and all the achieved data were statistically analyzed.
Results: A total of 154 patients were included. The distribution across mild (27.3%), moderate (33.7%), and severe (39%) lung involvement in COVID-19 was observed. Notably, levels of IL-6 (P=0.002), D-dimer (P=0.035), and LDH (P<0.001) exhibited variations among these three groups of COVID-19 lung involvement. Furthermore, statistically significant positive correlations were observed between the calculated lung involvement score and plasma levels of IL-6 (P=0.008, r= 0.280), D-dimer (P=0.008, r= 0.307), and LDH (P<0.001, r= 0.320).
Conclusion: This study suggests that plasma levels of biomarkers, including IL-6, D-dimer, and LDH, may be associated with lung involvement in COVID-19 patients.

 
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Type of Study: Brief Report | Subject: infection

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