Volume 35, Issue 244 (5-2025)
J Mazandaran Univ Med Sci 2025, 35(244): 169-175 |
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Marzhoseyni Z, Shaghaghi Z, Alvandi M, Hashemi S H, Ghasemi basir M, Mohamadi T et al . Correlation Between Serum Ferritin Levels and COVID-19 Severity: A Retrospective Cross-Sectional Study. J Mazandaran Univ Med Sci 2025; 35 (244) :169-175
URL: http://jmums.mazums.ac.ir/article-1-20796-en.html
URL: http://jmums.mazums.ac.ir/article-1-20796-en.html
Zeynab Marzhoseyni 
, Zahra Shaghaghi , Maryam Alvandi , Seyyed Hamid Hashemi , Mohammadreza Ghasemi basir , Tieyb Mohamadi , Soghra Farzipour
, Zahra Shaghaghi , Maryam Alvandi , Seyyed Hamid Hashemi , Mohammadreza Ghasemi basir , Tieyb Mohamadi , Soghra Farzipour
Abstract: (198 Views)
Background and purpose: The levels of serum ferritin increase with increasing disease severity, thereby suggesting a possible biomarker for the prediction of the cytokine storm. This study was carried out to evaluate the practical utility of ferritin as a serum biomarker in COVID-19.
Materials and methods: In this retrospective study, a total of 117 adult hospitalized patients with COVID-19 infection were included. The disease was diagnosed based on clinical signs and chest radiography, followed by real-time PCR. Patients were classified into mild-to-moderate (n= 47), severe (n = 46), and critical (n = 24) groups. Demographic and clinical information, as well as laboratory findings, were collected, and the concentrations of ferritin were compared among the different groups.
Results: The highest percentage of patients were in the critical group (76/29%). Overall, COVID-19 infection was more prevalent in females (66%) and the median age of patients in the critical group (76.29) was more than the other ones. The amount of ferritin was significantly higher in the critical (p< 0.001) group. The level of ferritin remarkably was higher in dead patients (620.88 ng/mL. Based on logistic regression analysis and ROC curve, ferritin can be a biomarker to predict high-risk patients. Furthermore, binary logistic regression showed ferritin to be a predictor of mortality supplemented.
Conclusion: Serum ferritin is a promising biomarker for anticipating cytokine storm, which may support clinical decision-making and contribute to the optimal management of patients with COVID-19.
Materials and methods: In this retrospective study, a total of 117 adult hospitalized patients with COVID-19 infection were included. The disease was diagnosed based on clinical signs and chest radiography, followed by real-time PCR. Patients were classified into mild-to-moderate (n= 47), severe (n = 46), and critical (n = 24) groups. Demographic and clinical information, as well as laboratory findings, were collected, and the concentrations of ferritin were compared among the different groups.
Results: The highest percentage of patients were in the critical group (76/29%). Overall, COVID-19 infection was more prevalent in females (66%) and the median age of patients in the critical group (76.29) was more than the other ones. The amount of ferritin was significantly higher in the critical (p< 0.001) group. The level of ferritin remarkably was higher in dead patients (620.88 ng/mL. Based on logistic regression analysis and ROC curve, ferritin can be a biomarker to predict high-risk patients. Furthermore, binary logistic regression showed ferritin to be a predictor of mortality supplemented.
Conclusion: Serum ferritin is a promising biomarker for anticipating cytokine storm, which may support clinical decision-making and contribute to the optimal management of patients with COVID-19.
Type of Study: Brief Report |
Subject:
infection
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