Volume 35, Issue 253 (1-2026)
J Mazandaran Univ Med Sci 2026, 35(253): 42-52 |
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Madadi R, Porkarimi Fatideh B, Firouzi M, Motedayen M, Karamitanha F, Ramazani A. Effectiveness and Side Effects of Antiplatelet and Anticoagulant Therapy in Patients with Coronary Artery Ectasia: A Clinical Trial. J Mazandaran Univ Med Sci 2026; 35 (253) :42-52
URL: http://jmums.mazums.ac.ir/article-1-22229-en.html
URL: http://jmums.mazums.ac.ir/article-1-22229-en.html
Reza Madadi 
, Behnoush Porkarimi Fatideh , Mohadese Firouzi , Morteza Motedayen , Farzaneh Karamitanha , Ali Ramazani
, Behnoush Porkarimi Fatideh , Mohadese Firouzi , Morteza Motedayen , Farzaneh Karamitanha , Ali Ramazani
Abstract: (36 Views)
Background and purpose: Although coronary artery ectasia is relatively common, there is currently no scientific consensus on the optimal antithrombotic therapy for these patients. This study aimed to evaluate the efficacy and safety of antiplatelet and anticoagulant therapies in individuals with coronary artery ectasia.
Materials and methods: In this clinical trial, 106 patients diagnosed with coronary artery ectasia were recruited from Ayatollah Mousavi Hospital, Zanjan. Patients were first stratified based on the need for stenting and then randomly assigned within each stratum to one of two treatment subgroups: combined antiplatelet and anticoagulant therapy or antiplatelet therapy alone. The primary outcomes included the incidence of major adverse cardiac and cerebrovascular events (MACCE), mortality, myocardial infarction (MI), cerebrovascular accident (CVA), hospital readmission, and bleeding complications. Data were analysed using appropriate statistical tests, with significance defined as P < 0.05.
Results: Regarding the distribution of involved vessels, three common patterns were observed: LCX + LAD + RCA involvement in 28 patients (26.4%), LAD involvement in 20 patients (18.9%), and RCA + LAD involvement in 20 patients (18.9%). Overall, most patients experienced no major adverse cardiac and cerebrovascular events (MACCE). However, among patients who underwent stenting, those treated with dual antiplatelet therapy (DAPT) combined with anticoagulants had a better prognosis, and this difference was statistically significant (P= 0.043). No major bleeding events were reported, and the incidence of minor bleeding did not differ significantly between groups.
Conclusion: In patients with coronary artery ectasia undergoing stenting, combined antiplatelet and anticoagulant therapy was associated with improved prognosis. Given the low incidence of bleeding complications, this approach may be considered an effective and safe treatment option for this patient population.
(Clinical Trials Registry Number: IRCT20210110049984N1)
Materials and methods: In this clinical trial, 106 patients diagnosed with coronary artery ectasia were recruited from Ayatollah Mousavi Hospital, Zanjan. Patients were first stratified based on the need for stenting and then randomly assigned within each stratum to one of two treatment subgroups: combined antiplatelet and anticoagulant therapy or antiplatelet therapy alone. The primary outcomes included the incidence of major adverse cardiac and cerebrovascular events (MACCE), mortality, myocardial infarction (MI), cerebrovascular accident (CVA), hospital readmission, and bleeding complications. Data were analysed using appropriate statistical tests, with significance defined as P < 0.05.
Results: Regarding the distribution of involved vessels, three common patterns were observed: LCX + LAD + RCA involvement in 28 patients (26.4%), LAD involvement in 20 patients (18.9%), and RCA + LAD involvement in 20 patients (18.9%). Overall, most patients experienced no major adverse cardiac and cerebrovascular events (MACCE). However, among patients who underwent stenting, those treated with dual antiplatelet therapy (DAPT) combined with anticoagulants had a better prognosis, and this difference was statistically significant (P= 0.043). No major bleeding events were reported, and the incidence of minor bleeding did not differ significantly between groups.
Conclusion: In patients with coronary artery ectasia undergoing stenting, combined antiplatelet and anticoagulant therapy was associated with improved prognosis. Given the low incidence of bleeding complications, this approach may be considered an effective and safe treatment option for this patient population.
(Clinical Trials Registry Number: IRCT20210110049984N1)
Type of Study: Research(Original) |
Subject:
Cardiovascular
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