Volume 23, Issue 101 (6-2013)                   J Mazandaran Univ Med Sci 2013, 23(101): 11-18 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Valizadeh F, Deylami A. Prevalence of Hemoglobin E in Premarital Screening, Babolsar, Iran (2006-2011). J Mazandaran Univ Med Sci 2013; 23 (101) :11-18
URL: http://jmums.mazums.ac.ir/article-1-2250-en.html
Abstract:   (16997 Views)
Background and purpose: Throughout the world 5.2% of the population is carrier for a main hemoglobin disorder. Mazandaran province in North of Iran is highly influenced by heterozygote advantage resulting in high prevalence of hemoglobinopathies. Hemoglobin E is one of the beta globin variants that can cause severe anemia such as thalassemia major. Materials and methods: This descriptive study was carried out in 750 individuals (375female and 375 male) with microcytic hypochromic anemia (MCH<27, MCV<80) attending thalassemia counseling center in Babolsar, during 2006-2011. Hemoglobin electrophoresis and genetic tests were performed to determine the type of α, β or other rare forms of thalassemia. Results: Among the subjects 297 had high HbA2 and were classified as beta thalassemia minor carriers. There were 403 cases with normal HbA2 and 50 had excessive-Hgb band. In acidic electrophoresis and HPLC 20 people were found with HgbE band. To confirm the diagnosis DNA analysis was performed for 10 cases and Glu26 Lys (HgbE) was confirmed. Conclusion: This study showed high incidence of hemoglobinopathies in Mazandaran province. Therefore, it is important to evaluate the beta globin variants such as HgbE to prevent more thalassemia major in the region.
Full-Text [PDF 204 kb]   (2665 Downloads)    
Type of Study: Research(Original) | Subject: psychology

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Mazandaran University of Medical Sciences

Designed & Developed by : Yektaweb