Volume 19, Issue 71 (Jul 2009)                   J Mazandaran Univ Med Sci 2009, 19(71): 20-26 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Shamsizadeh A, Sheibani V, Sepehri G, Azarang A, Namjoo A. Differences of intensities regarding withdrawal signs in experimental methods For inducing morphine dependency. J Mazandaran Univ Med Sci 2009; 19 (71) :20-26
URL: http://jmums.mazums.ac.ir/article-1-560-en.html
Abstract:   (11498 Views)
Background and purpose: In the present study, we compared the intensity of physical dependency, mortality rate and weight changes in some common methods for inducing morphine dependency.
Materials and methods: Six common different methods for morphine dependency were chosen in wistar rats. In all methods, morphine dependency was induced by repeated morphine injection. Precipitation of morphine withdrawal signs were performed on the last day in each method, 4 hours after the last morphine injection for 20 minutes. The withdrawal signs included: vertical jumping, wet dog shakes, diarrhea, teeth chattering, ptosis, head shakes and rearing.
Results: Our results demonstrated that all groups of treated rats showed withdrawal signs following naloxone challenge. However, the intensities of withdrawal signs (vertical jumping, wet dog shakes, diarrhea, teeth chattering, head shakes and rearing) were significantly different among these methods. Also, mortality rate and amount of weight loss were significantly different among the different methods.
Conclusion: This study demonstrates that different experimental methods of morphine dependency can induce different intensities of withdrawal signs, mortality rate and weight loss.
Full-Text [PDF 301 kb]   (2328 Downloads)    
Type of Study: Research(Original) |

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2023 CC BY-NC 4.0 | Journal of Mazandaran University of Medical Sciences

Designed & Developed by : Yektaweb