Volume 19, Issue 73 (Sep 2009)
J Mazandaran Univ Med Sci 2009, 19(73): 80-83 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Kazemi Arababadi M, Pourfathollah A, Hassanshahi G, Pooladvand V, Yaghini N, Shamsyzadeh A. Evaluation of serum level of IL-12 in patients withoccult HBV infection. J Mazandaran Univ Med Sci 2009; 19 (73) :80-83
URL: http://jmums.mazums.ac.ir/article-1-592-en.html
URL: http://jmums.mazums.ac.ir/article-1-592-en.html
M Kazemi Arababadi 
, A.A Pourfathollah , GH.H Hassanshahi , V Pooladvand , N Yaghini , A Shamsyzadeh
, A.A Pourfathollah , GH.H Hassanshahi , V Pooladvand , N Yaghini , A Shamsyzadeh
Abstract: (13733 Views)
Background and purpose:Occult hepatitis B infection (OBI) is a form of hepatitis in which despite the absence of detectable HBsAg, HBV-DNA is present in peripheral blood of patients. Investigators believed that the genetics and immunological parameters may be different in resistant individuals and patients. Cytokines, such as IL-12, could be leading to alteration in viral immune response. The main aim of this study was to investigate the serum level of IL12 in OBI patients.
Materials and methods:In this study, the plasma samples of 3700 HBsAg negative blood donors were tested for anti-HBs by ELISA. The HBsAg negative and anti-HBc positive samples were selected and screened for HBV-DNA by PCR. HBV-DNA positive samples were assigned as OBI cases and ELISA technique were performed to examine the serum level of IL-12 in OBI and 100 healthy controls.
Results:Our results showed that there was no significant difference in serum level of IL-12 between OBI patients and controls.
Conclusion:In order to be clear of viruses, L-12 is increased in viral infection. Based on the results of this study, it is concluded that OBI patients can not produce enough IL-12 to clear HBV.
Materials and methods:In this study, the plasma samples of 3700 HBsAg negative blood donors were tested for anti-HBs by ELISA. The HBsAg negative and anti-HBc positive samples were selected and screened for HBV-DNA by PCR. HBV-DNA positive samples were assigned as OBI cases and ELISA technique were performed to examine the serum level of IL-12 in OBI and 100 healthy controls.
Results:Our results showed that there was no significant difference in serum level of IL-12 between OBI patients and controls.
Conclusion:In order to be clear of viruses, L-12 is increased in viral infection. Based on the results of this study, it is concluded that OBI patients can not produce enough IL-12 to clear HBV.
Type of Study: Research(Original) |
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Articles Copyright © The Author(s). Owned by Mazandaran University of Medical Sciences.
Contact Us
Address: Journal Office, Building No. 2, Mazandaran University of Medical Sciences, Moallem Square, Sari.Tel: +98 (011)34484874 Postal code: 48175-866 E-Mail: jmums@mazums.ac.ir Telefax: +98 (011)33262679
