Volume 13, Issue 40 (Sep 2003)
J Mazandaran Univ Med Sci 2003, 13(40): 61-69 |
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Saeedi M, Âzadbakht M, Semnani K, Khandan M. Formulation of herbal toothpaste from Chamomile and Myrrh, a preliminary clinical evaluation on bleeding gum . J Mazandaran Univ Med Sci 2003; 13 (40) :61-69
URL: http://jmums.mazums.ac.ir/article-1-775-en.html
URL: http://jmums.mazums.ac.ir/article-1-775-en.html
Abstract: (71584 Views)
Background and purpose: Many plants extracts or their derivatives have been used in commercial toothpastes to treat periodontal diseases in the world. Çhamomile has healing property with anti bacterial and antifungal activities and also is applied topically to relieve pain. Myrrh has been used as an antiseptic, antifungal and anti inflammatory, also used as an astringent to mucous membranes, as a gargle or mouth wash for inflammation of the mouth.
This is a study on formulation of tooth paste containing these two plants products as a preliminary clinical evaluation about relieving property of this prepration on bleeding gum.
Materials and methods: Ïn this research, after formulation of several toothpastes (23 formulations) and evaluation of their physical stability (at 4oc, 25oc and 40oc), quality (pH, microbial control, etc) and presence of active ingredients in tincture of myrrh, chamomile extract and peppermint oil the effects of preparations containing myrrh (1%), chamomile (1.5%) (F21) and Myrrh (1%) itself (F22) were evaluated on bleeding gum. Ïn this double blind study, 49 volunteers with bleeding gum were under placebo control for two weeks.
Results : Glycerin and Polyethyleneglycole 200 were selected as best cosolvents for preparation of toothpaste. Çonsidering the evaluation of the prepared formulation carboxy methyl cellulose (as a gelling agent) and tri-calcium phosphate (as abrasive) caused more stability of formulations. 49 volunteers with bleeding gums took part in this double blind, placebo – controlled, clinical trial for 2 weeks. The results indicated significant effect of F21 and F22 on bleeding gum compare with placebo (P < 0.05 and P < 0.001 respectively).
Çonclusion: The present study suggests that this toothpaste can be introduced as an effective preparation on bleeding gum.
Materials and methods: Ïn this research, after formulation of several toothpastes (23 formulations) and evaluation of their physical stability (at 4oc, 25oc and 40oc), quality (pH, microbial control, etc) and presence of active ingredients in tincture of myrrh, chamomile extract and peppermint oil the effects of preparations containing myrrh (1%), chamomile (1.5%) (F21) and Myrrh (1%) itself (F22) were evaluated on bleeding gum. Ïn this double blind study, 49 volunteers with bleeding gum were under placebo control for two weeks.
Results : Glycerin and Polyethyleneglycole 200 were selected as best cosolvents for preparation of toothpaste. Çonsidering the evaluation of the prepared formulation carboxy methyl cellulose (as a gelling agent) and tri-calcium phosphate (as abrasive) caused more stability of formulations. 49 volunteers with bleeding gums took part in this double blind, placebo – controlled, clinical trial for 2 weeks. The results indicated significant effect of F21 and F22 on bleeding gum compare with placebo (P < 0.05 and P < 0.001 respectively).
Çonclusion: The present study suggests that this toothpaste can be introduced as an effective preparation on bleeding gum.
Type of Study: Research(Original) |
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