Background and purpose: Contradictory evidences indicate that gestational diabetes mellitus (GDM) increase the risk of spontaneous abortion (SA). Therefore, in a systematic review and meta- analysis we investigated the association between GDM and SA.
Materials and methods: Relevant articles published between January 2000 and April 2016 were identified by a systematic search in national and international databases. Eligible studies were included in meta-analysis after quality assessment. We also determined the heterogenic index using Cochran’s test (Q) and I2. Based on the heterogenetic results, a random effect model was performed to combine the results. Stata software was used for data analyses.
Results: A total of 26 studies was included in current meta-analysis in which SA was reported in 2280 pregnant women with GDM. But in 24145 pregnant women without GDM SA occurred in 2386. Significant heterogeneity was observed between the results (P< 0.001, I-square=68.3, Q=30.6). According to the findings, total odds ratio of SA among pregnant women with GDM was 3.01 times more than that in pregnant women without GDM (95% CI: 2.38–3.82).
Conclusion: Appropriate control and screening for GDM in pregnant women could reduce the risk of SA.