Volume 29, Issue 180 (12-2019)
J Mazandaran Univ Med Sci 2019, 29(180): 95-101 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Mahdavifard S, Nakhjavani M. Effect of Cysteine on Transforming Growth Factor
β1 as the Main Cause of Renal Disorder in a
Rat Model of Diabetic Nephropathy. J Mazandaran Univ Med Sci 2019; 29 (180) :95-101
URL: http://jmums.mazums.ac.ir/article-1-14036-en.html
URL: http://jmums.mazums.ac.ir/article-1-14036-en.html
Abstract: (2679 Views)
Background and purpose: Glycation products, oxidative stress, and inflammation contribute to the development of diabetic nephropathy (DN) due to the elevation of transforming growth factor-β1 (TGF-β1). This study aimed at investigating the effect of Cysteine (Cys) on TGF-β in DN rat model.
Materials and methods: In this experimental study, 40 male Wistar rats were randomly divided into four groups (n=10 per group): control, Cys, DN, and DN + Cys. DN was induced in rats by nephrectomy of the left kidney and injection of streptozotocin. The Cys and DN groups were treated with Cys (0.05% in dirking water) for three months. Glucose, insulin, diverse glycation products, lipid profile, oxidative stress markers, TNF-α, proteinuria, and serum creatinine levels were determined in all rats. Data analysis was done in SPSS V16.
Results: Cys decreased the sera level of TGF-β1, renal dysfunction parameters, diverse Glycation, oxidative stress, and inflammatory markers in DN rats. Furthermore, the treatment improved glycemia and dyslipidemia (P> 0.001).
Conclusion: Cysteine with antioxidant, anti-glycating, and anti-inflammatory properties ameliorated DN owing to advantageous effects on glucose and lipid metabolism in rats with diabetic nephropathy. Furthermore, this treatment showed multiple protective effects on kidney by reducing the TGF- β1 levels.
Materials and methods: In this experimental study, 40 male Wistar rats were randomly divided into four groups (n=10 per group): control, Cys, DN, and DN + Cys. DN was induced in rats by nephrectomy of the left kidney and injection of streptozotocin. The Cys and DN groups were treated with Cys (0.05% in dirking water) for three months. Glucose, insulin, diverse glycation products, lipid profile, oxidative stress markers, TNF-α, proteinuria, and serum creatinine levels were determined in all rats. Data analysis was done in SPSS V16.
Results: Cys decreased the sera level of TGF-β1, renal dysfunction parameters, diverse Glycation, oxidative stress, and inflammatory markers in DN rats. Furthermore, the treatment improved glycemia and dyslipidemia (P> 0.001).
Conclusion: Cysteine with antioxidant, anti-glycating, and anti-inflammatory properties ameliorated DN owing to advantageous effects on glucose and lipid metabolism in rats with diabetic nephropathy. Furthermore, this treatment showed multiple protective effects on kidney by reducing the TGF- β1 levels.
Type of Study: Brief Report |
Subject:
Nephrology
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Articles Copyright © The Author(s). Owned by Mazandaran University of Medical Sciences.
Contact Us
Address: Journal Office, Building No. 2, Mazandaran University of Medical Sciences, Moallem Square, Sari.Tel: +98 (011)34484874 Postal code: 48175-866 E-Mail: jmums@mazums.ac.ir Telefax: +98 (011)33262679
