Volume 30, Issue 192 (1-2021)
J Mazandaran Univ Med Sci 2021, 30(192): 35-43 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Jafari Anarloie M, Azadbakht M, Asgarirad H, Rahmatpour-Rokni G, Davoodi A, Farmoudeh A. Formulation, Preparation and Evaluation of Antiperspirant Effects of Hydrogel of Salvia virgata Jacq Aerial Part: A Randomized, Double Blind and Placebo-Controlled Clinical Trial. J Mazandaran Univ Med Sci 2021; 30 (192) :35-43
URL: http://jmums.mazums.ac.ir/article-1-14551-en.html
URL: http://jmums.mazums.ac.ir/article-1-14551-en.html
Mona Jafari Anarloie 
, Mohammad Azadbakht , Hossein Asgarirad , Ghasem Rahmatpour-Rokni , Ali Davoodi , Ali Farmoudeh
, Mohammad Azadbakht , Hossein Asgarirad , Ghasem Rahmatpour-Rokni , Ali Davoodi , Ali Farmoudeh
Abstract: (2129 Views)
Background and purpose: Salvia virgata Jacq has antioxidant, antibacterial, anti-inflammatory, antinociceptive, antispasmodic, and healing effects. The aim of this study was to prepare and antiperspirant clinical evaluation of aerial gel formulation of this plant.
Materials and methods: The aerial parts of the plant were collected from Hezarjarib forest in Mazandaran, spring 2017. The samples were crushed, dried and extracted with 70% ethanol. The amount of total flavonoids of the extract was investigated by spectrophotometric method of Aluminum Chloride with Quercetin standard. For antiperspirant clinical study, 5% gel formulation of dried extract was prepared. The gel was formulated by carbopol 980, glycerin, methyl, propylparaben, triethanolamine, and 5% dried plant extract. Then, physicochemical and microbial properties of the product, including stability, consistency, viscosity, dispersibility, transparency, color, odor, and bacteria growth were investigated in general and specific culture media. After preparation, in this randomized double-blind study, the products and placebos were administered to the volunteers (twice daily). Hyperhidrosis Disease Severity Scale (HDSS) was completed and clinical indicators were evaluated.
Results: In this study, the extract yield and total flavonoid content of the extract were 39.88% and 49.83 mg/g, respectively. In addition, 1% carbopol formulation had good physicochemical properties and significant difference was seen in the efficacy of the drug between the intervention and placebo group (P<0.05).
Conclusion: According to current study, Salvia virgata Jacq is suitable in treatment of hyperhidrosis.
Materials and methods: The aerial parts of the plant were collected from Hezarjarib forest in Mazandaran, spring 2017. The samples were crushed, dried and extracted with 70% ethanol. The amount of total flavonoids of the extract was investigated by spectrophotometric method of Aluminum Chloride with Quercetin standard. For antiperspirant clinical study, 5% gel formulation of dried extract was prepared. The gel was formulated by carbopol 980, glycerin, methyl, propylparaben, triethanolamine, and 5% dried plant extract. Then, physicochemical and microbial properties of the product, including stability, consistency, viscosity, dispersibility, transparency, color, odor, and bacteria growth were investigated in general and specific culture media. After preparation, in this randomized double-blind study, the products and placebos were administered to the volunteers (twice daily). Hyperhidrosis Disease Severity Scale (HDSS) was completed and clinical indicators were evaluated.
Results: In this study, the extract yield and total flavonoid content of the extract were 39.88% and 49.83 mg/g, respectively. In addition, 1% carbopol formulation had good physicochemical properties and significant difference was seen in the efficacy of the drug between the intervention and placebo group (P<0.05).
Conclusion: According to current study, Salvia virgata Jacq is suitable in treatment of hyperhidrosis.
Type of Study: Research(Original) |
Subject:
Pharmacognosy
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Articles Copyright © The Author(s). Owned by Mazandaran University of Medical Sciences.
Contact Us
Address: Journal Office, Building No. 2, Mazandaran University of Medical Sciences, Moallem Square, Sari.Tel: +98 (011)34484874 Postal code: 48175-866 E-Mail: jmums@mazums.ac.ir Telefax: +98 (011)33262679
