Volume 33, Issue 225 (10-2023)
J Mazandaran Univ Med Sci 2023, 33(225): 103-115 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Zamaniyan M, Razian K, Peyvandi S, Moosazadeh M, Hamedi M, Zahedi M et al . A Comparison Between the Effects of Letrozole in Combination with Clomiphene and Letrozole Alone on Ovulation and Pregnancy in Infertile Patients with Polycystic Ovarian Syndrome: A Clinical Trial Study. J Mazandaran Univ Med Sci 2023; 33 (225) :103-115
URL: http://jmums.mazums.ac.ir/article-1-15272-en.html
URL: http://jmums.mazums.ac.ir/article-1-15272-en.html
Marzieh Zamaniyan 
, Kosar Razian , Sepideh Peyvandi , Mahmood Moosazadeh , Masoomeh Hamedi , Mohammad Zahedi , Ensieh Fooladi
, Kosar Razian , Sepideh Peyvandi , Mahmood Moosazadeh , Masoomeh Hamedi , Mohammad Zahedi , Ensieh Fooladi
Abstract: (1401 Views)
Background and purpose: Infertility is defined as the inability to conceive after 12 months of regular coitus. Anovulatory processes are the most common cause of infertility in women. The aim of this study was to compare the efficacy of combination treatment of clomiphene citrate (CC) and letrozole versus letrozole alone for ovulation induction and pregnancy rate in infertile women with polycystic ovarian syndrome (PCOS).
Materials and methods: This is a single-blind, controlled trial study. A total of 102 infertile PCOS women were randomly divided into two groups. Group one (n=51) received 100 mg CC plus 5 mg letrozole daily on cycle days 3-7 for a single treatment cycle and group two (n=51) received 5 mg letrozole daily on cycle days 3-7 for a single treatment cycle. When at least one follicle reached a diameter of 18-19 mm, the patients received human gonadotropin hormone (5000 U-IV injection). The couples had regular intercourse, 2-3 times a week, as they had been instructed.
Results: The number of follicles with a diameter of 14 mm was significantly higher in women who received the combination treatment of letrozole and clomiphene compared to the ones who received letrozole treatment (P=0.04). There were no statisticaly significant differences in the number of 18 mm follicles (P=0.07), mean endometrial thickening (P=0.37), clinical pregnancy rate (P=0.99), ongoing pregnancy rate (P=0.59), multiple pregnancy rate (P=0.99), and live birth (P= 0.99) between the two groups.
Conclusion: According to our study, the combination treatment of letrozole and CC is more effective than letrozole and can be used as the first-line therapy for infertility in women with PCOS. Moreover, the cost and risk of this treatment may be lower than other induction ovulation treatments.
Materials and methods: This is a single-blind, controlled trial study. A total of 102 infertile PCOS women were randomly divided into two groups. Group one (n=51) received 100 mg CC plus 5 mg letrozole daily on cycle days 3-7 for a single treatment cycle and group two (n=51) received 5 mg letrozole daily on cycle days 3-7 for a single treatment cycle. When at least one follicle reached a diameter of 18-19 mm, the patients received human gonadotropin hormone (5000 U-IV injection). The couples had regular intercourse, 2-3 times a week, as they had been instructed.
Results: The number of follicles with a diameter of 14 mm was significantly higher in women who received the combination treatment of letrozole and clomiphene compared to the ones who received letrozole treatment (P=0.04). There were no statisticaly significant differences in the number of 18 mm follicles (P=0.07), mean endometrial thickening (P=0.37), clinical pregnancy rate (P=0.99), ongoing pregnancy rate (P=0.59), multiple pregnancy rate (P=0.99), and live birth (P= 0.99) between the two groups.
Conclusion: According to our study, the combination treatment of letrozole and CC is more effective than letrozole and can be used as the first-line therapy for infertility in women with PCOS. Moreover, the cost and risk of this treatment may be lower than other induction ovulation treatments.
Type of Study: Research(Original) |
Subject:
Gynecology and Infertility
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Articles Copyright © The Author(s). Owned by Mazandaran University of Medical Sciences.
Contact Us
Address: Journal Office, Building No. 2, Mazandaran University of Medical Sciences, Moallem Square, Sari.Tel: +98 (011)34484874 Postal code: 48175-866 E-Mail: jmums@mazums.ac.ir Telefax: +98 (011)33262679
