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There are evidences on the efficacy of several venotonics in improving postoperative symptoms, including bleeding, pain, etc. A thorough search was conducted in Google Scholar, PubMed, and Cochrane Library covering the articles published in 2000–2020. We included trials assessing the efficacy of phlebotonics in patients with chronic venous insufficiency and other venous diseases or traumas. Findings suggest superiority of phlebotonic agents over placebo and control treatments in management of common symptoms after phlebectomies, coronary bypass grafting, and other interventions. Significant alleviation of post-procedural symptoms, including pain severity were reported in the majority of patients treated with venotonics. There were no adverse reactions associated with administration of phlebotonic drugs. Nonetheless, further high-quality trials are necessary to support this conclusion.

Keywords: venotonics, postoperative care, hemorrhage, edema, venous insufficiency

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