Volume 22, Issue 96 (12-2012)
J Mazandaran Univ Med Sci 2012, 22(96): 22-29 |
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Namjoo A, Sadri S M, Rafeian M, Ashrafi K, Shahin Fard N, Ansari samani R et al . Comparing the Effects of Nigella Sativa Extract and Gentamicin in Treatment of Urinary Tract Infection Caused by Ecoli. J Mazandaran Univ Med Sci 2012; 22 (96) :22-29
URL: http://jmums.mazums.ac.ir/article-1-1635-en.html
URL: http://jmums.mazums.ac.ir/article-1-1635-en.html
Abdolrasoul Namjoo 
, Seyed Morteza Sadri , Mahmoud Rafeian , Kooroush Ashrafi , Najmeh Shahin Fard , Rouya Ansari samani , Fatemeh Moosavi Azmareh
, Seyed Morteza Sadri , Mahmoud Rafeian , Kooroush Ashrafi , Najmeh Shahin Fard , Rouya Ansari samani , Fatemeh Moosavi Azmareh
Abstract: (35119 Views)
Background and purpose: The antibiotics’ side effects and microbial resistance have increased the need for natural antimicrobial agents in treating infections. This study aimed to investigate the antimicrobial effects of Nigella sativa extract and its possible nephrotoxicity compared with gentamicin. The effect of N. sativa on gentamicin induced renal toxicity and its synergistic effect were evaluated on urinary tract infection caused by Ecoli in rabbits.
Materials and methods: In this experimental study, 36 male New Zealand rabbits were designated into seven groups: gentamicin-bacteria, N. sativa-bacteria, N. sativa-gentamicin-bacteria,
N. sativa-gentamicin, bacteria, gentamicin and control groups. The animals were anesthetized after ten days of treatment, and the kidney specimens were collated for histopathological examination. The nephrotoxic effects of gentamicin and protective effects of N. sativa on kidney were studied. Antibacterial effects of the extracts were evaluated with laboratory tests and the MBC and MIC values were obtained for N. sativa.
Results: The level of urea nitrogen and creatinine in urine increased in bacteria group compared to control group (P<0.05). But, they decreased in bacteria- N. sativa group compared with the bacterial group (P<0.05). Histopathological examination of kidney tissue showed that renal lesions in bacterial and, bacteria- gentamicin groups (ATN) were more than N. sativa -bacteria and bacteria-gentamycin- N. sativa (minor necrosis) groups.
Conclusion: According to the results, N. sativa in addition to antibacterial effect against E. coli, can prevent the nephrotoxic effects of gentamicin. Therefore, it may be considered as an alternative, or in combination with gentamicin.
Keywords: Nigella sativa extract, gentamicin, rabbit, urinary infection, nephrotoxicity, histopathology
Type of Study: Research(Original) |
Subject:
urology
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