Volume 31, Issue 199 (8-2021)                   J Mazandaran Univ Med Sci 2021, 31(199): 174-178 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Oladnabi M, Hasheminasabgorji E, Mohammadi M, Lotfi S, Hamlevar J, Dastaviz F et al . Hereditary and Non-hereditary Pattern of Deafness in Golestan Province, Iran. J Mazandaran Univ Med Sci 2021; 31 (199) :174-178
URL: http://jmums.mazums.ac.ir/article-1-16363-en.html
Abstract:   (1245 Views)
Background and purpose: Hearing impairment as a heterogeneous disorder is the most common sensory defect. Genetic (hereditary) hearing loss involves 50% of total cases and the remaining 50% are non-hereditary cases caused by unknown causes. This study aimed to investigate the role of consanguineous marriage and the relationship between the type of deafness and the hereditary pattern in families with more than one deaf patient in Golestan province, Iran.
Materials and methods: The study population included 165 families with deaf members whose files were available in the General Welfare Department of Golestan Province. They were randomly selected during 2018-2019. Data, including number of family members with hearing loss and severity of the condition were collected by face-to-face interviews with parents. Data analysis was done in SPSS.
Results: The mean age of the subjects was 27.67±9.71. Female and male cases included 42.1% and 57.9%, respectively. In 85% of the cases, genetic factor and in 15% acquired factors were responsible for hearing loss. Among the genetic causes, 90.9% of the population were autosomal recessive and 9.1% were autosomal dominant. Moreover, 70% of families had consanguineous marriage and first-degree family relationship was seen in 92 families (80%).
Conclusion: Genetic factor with the autosomal recessive inheritance pattern was the most common cause of hearing loss in the population studied. Increasing awareness about the consequences of consanguineous marriage and genetic counseling are indispensable in decreasing the rate of this condition.
Full-Text [PDF 2499 kb]   (596 Downloads)    
Type of Study: Brief Report | Subject: Audiology

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Mazandaran University of Medical Sciences

Designed & Developed by : Yektaweb