Volume 32, Issue 208 (4-2022)
J Mazandaran Univ Med Sci 2022, 32(208): 135-140 |
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Toghani Hulari F, Esmaili M, Akbari M, Khajenabi F, Abediankenari S. Frequency of Major Histocompatibility Antigens Class I in Mazandaran Province. J Mazandaran Univ Med Sci 2022; 32 (208) :135-140
URL: http://jmums.mazums.ac.ir/article-1-18111-en.html
URL: http://jmums.mazums.ac.ir/article-1-18111-en.html
Fatemeh Toghani Hulari 
, Mozhgan Esmaili , Mohammad Akbari , Fatemeh Khajenabi , Saeid Abediankenari
, Mozhgan Esmaili , Mohammad Akbari , Fatemeh Khajenabi , Saeid Abediankenari
Abstract: (1516 Views)
Background and purpose: Major histocompatibility antigens are the most polymorphic components of the immune system. The purpose of this study was to determine the frequency of human leukocyte antigens (HLA) in a population in Mazandaran province, Iran.
Materials and methods: In a cross sectional study, peripheral blood samples were obtained from 550 people in Immunogenetics Research Center affiliated with Mazandaran University of Medical Sciences, 2016-2021. The types of HLA class 1 antigens (A-B-C) were studied using SSP-PCR.
Results: HLA-A * 24, HLA-B * 35 and HLA-C * 04 were found to be the most common alleles in the population studied.
Conclusion: HLA diversity plays a major role in developing some diseases. So, it should be investigated in anthropological studies and finding a suitable donor in bone marrow transplantation. In fact, more extensive studies are required to draw a new horizon in the association between HLA and diseases in different ethnicities.
Materials and methods: In a cross sectional study, peripheral blood samples were obtained from 550 people in Immunogenetics Research Center affiliated with Mazandaran University of Medical Sciences, 2016-2021. The types of HLA class 1 antigens (A-B-C) were studied using SSP-PCR.
Results: HLA-A * 24, HLA-B * 35 and HLA-C * 04 were found to be the most common alleles in the population studied.
Conclusion: HLA diversity plays a major role in developing some diseases. So, it should be investigated in anthropological studies and finding a suitable donor in bone marrow transplantation. In fact, more extensive studies are required to draw a new horizon in the association between HLA and diseases in different ethnicities.
Keywords: frequency, major histocompatibility antigens
Type of Study: Brief Report |
Subject:
Immunology
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