Volume 32, Issue 217 (1-2023)                   J Mazandaran Univ Med Sci 2023, 32(217): 148-168 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Alvandi M, Shaghaghi Z, Dehbanpour M R, Farzipour S, Talebpour Amiri F. A Review of Effects of Atorvastatin in Radiotherapy. J Mazandaran Univ Med Sci 2023; 32 (217) :148-168
URL: http://jmums.mazums.ac.ir/article-1-18168-en.html
Abstract:   (674 Views)
 Radiation therapy is one of the major subsets of cancer treatments. Normal tissue toxicity and tumor cell resistance are two main obstacles during radiotherapy treatments. Toxicity to healthy tissue limits the applied dose, resulting in inadequate tumor control. On the other hand, the resistances of cancer cells lead to increased doses of radiotherapy. Therefore, agents that can simultaneously reduce the toxicity of normal tissues and increase the sensitivity of tumor cells to radiotherapy could be a potential solution to increase the efficiency of radiotherapy during cancer treatment. Many studies have found that atorvastatin, as an HMG coenzyme A reductase (HMG-CoA) inhibitor, and protects normal tissue while sensitizing cancer cells to radiotherapy via various molecular mechanisms and signaling pathways. This review summarizes the evidence for radioprotective and radiosensitivity effects of atorvastatin in vitro and in vivo studies.
 
Full-Text [PDF 480 kb]   (575 Downloads)    
Type of Study: Review | Subject: Clinical pharmacy

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Mazandaran University of Medical Sciences

Designed & Developed by : Yektaweb