Volume 35, Issue 250 (11-2025)
J Mazandaran Univ Med Sci 2025, 35(250): 192-197 |
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Alimoradi Sharifabadi H, Jalali Nadoushan M, Sedaghat Telgard M. Comparison of BCL-2 protein expression in nasal polyp and chronic rhinosinusitis. J Mazandaran Univ Med Sci 2025; 35 (250) :192-197
URL: http://jmums.mazums.ac.ir/article-1-20598-en.html
URL: http://jmums.mazums.ac.ir/article-1-20598-en.html
Abstract: (38 Views)
Background and purpose: Chronic rhinosinusitis is a common inflammatory disorder affecting the sinonasal mucosa, which can develop with or without nasal polyps. Identifying the mechanisms involved in nasal polyp development in patients with chronic rhinosinusitis could be useful in the prevention and treatment of these polyps. One of the suggested mechanisms in this context is increased cellular proliferation and apoptosis inhibition. The present study aims to compare the expression of the anti-apoptotic B-cell lymphoma 2 (BCL-2) protein in nasal polyps and chronic rhinosinusitis.
Materials and methods: In this cross-sectional study, a total of 70 nasal polyps and 60 chronic rhinosinusitis samples obtained from patients who were referred to Shahid Mostafa Khomeini Hospital, Tehran, during 2017 to 2021 were immunohistochemically stained using the BCL-2 marker. The percentage of BCL-2 expression was determined for each sample. Data were analyzed using SPSS statistical software, version 16, and the percentage of BCL-2 expression in the two groups and its association with patients' age and gender were evaluated.
Results: The mean percentage of BCL-2 expression in all samples was 23.09 ± 11.2 with a range of 0-62%. The mean percentage of BCL-2 expression in nasal polyps samples (26.58 ± 12.47) was significantly higher than that in chronic rhinosinusitis (19.01 ± 7.82) samples (P=0.001). In the nasal polyps group, the mean percentage of BCL-2 expression in male paitients was significantly higher than in female patients (P=0.008). There was also a significant positive correlation between the percentage of BCL-2 expression and patients' age in the nasal polyps group (P=0.027, R = 0.265(.
Conclusion: The findings of this study are suggestive of the role of BCL-2 overexpression as an anti-apoptotic protein in the development of nasal polyps in patients with chronic rhinosinusitis. This overexpression is predominantly observed in male patients and correlates positively with age.
Materials and methods: In this cross-sectional study, a total of 70 nasal polyps and 60 chronic rhinosinusitis samples obtained from patients who were referred to Shahid Mostafa Khomeini Hospital, Tehran, during 2017 to 2021 were immunohistochemically stained using the BCL-2 marker. The percentage of BCL-2 expression was determined for each sample. Data were analyzed using SPSS statistical software, version 16, and the percentage of BCL-2 expression in the two groups and its association with patients' age and gender were evaluated.
Results: The mean percentage of BCL-2 expression in all samples was 23.09 ± 11.2 with a range of 0-62%. The mean percentage of BCL-2 expression in nasal polyps samples (26.58 ± 12.47) was significantly higher than that in chronic rhinosinusitis (19.01 ± 7.82) samples (P=0.001). In the nasal polyps group, the mean percentage of BCL-2 expression in male paitients was significantly higher than in female patients (P=0.008). There was also a significant positive correlation between the percentage of BCL-2 expression and patients' age in the nasal polyps group (P=0.027, R = 0.265(.
Conclusion: The findings of this study are suggestive of the role of BCL-2 overexpression as an anti-apoptotic protein in the development of nasal polyps in patients with chronic rhinosinusitis. This overexpression is predominantly observed in male patients and correlates positively with age.
Type of Study: Brief Report |
Subject:
Pathology
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