Volume 35, Issue 249 (10-2025)
J Mazandaran Univ Med Sci 2025, 35(249): 72-83 |
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Panbekar Juybari N, Gholami F, Espahbodi F, Alipour A. Evaluation of Risk Factors for Mortality in Dialysis Patients with COVID-19 Referred to the Sari Shahrvand Dialysis
Center, 2020–2021. J Mazandaran Univ Med Sci 2025; 35 (249) :72-83
URL: http://jmums.mazums.ac.ir/article-1-20953-en.html
URL: http://jmums.mazums.ac.ir/article-1-20953-en.html
Abstract: (17 Views)
Background and purpose: The purpose of this study was to investigate the risk factors for COVID-19–related mortality among dialysis patients referred to the Sari Shahrvand Dialysis Center.
Materials and methods: The present study was a retrospective cohort study. The study population included patients undergoing dialysis treatment at the Sari Shahrvand Dialysis Center who had been on dialysis for at least three months following the onset of acute kidney disease, were in the end-stage renal disease (ESRD) phase, and had a confirmed diagnosis of COVID-19 (based on reports from accredited laboratories of Mazandaran University of Medical Sciences or characteristic findings on chest CT scans). Finally, various demographic, clinical, and laboratory parameters were compared between deceased and surviving patients.
Results: A total of 64 hemodialysis patients with COVID-19 were examined, of whom 33 (51.6%) died during the study period. Compared with surviving patients, deceased patients had significantly higher levels of CRP, AST, and ALT (P < 0.05 for all comparisons). Logistic regression analysis identified male sex, elevated body mass index (BMI), diabetes, cardiovascular disease, elevated CRP and ALT levels, and greater than 50% lung involvement as predictive factors of mortality in hemodialysis patients with COVID-19.
Conclusion: Considering that liver function tests are an integral part of routine biochemical investigations, are available in even the simplest laboratories in both urban and rural settings, and are relatively inexpensive and well standardized, abnormalities in liver function tests may serve as cost-effective markers of disease severity. These tests could therefore be valuable tools for family physicians, particularly at the community level, in assessing the severity of complications in patients with chronic kidney disease, especially hemodialysis patients affected by COVID-19.
Materials and methods: The present study was a retrospective cohort study. The study population included patients undergoing dialysis treatment at the Sari Shahrvand Dialysis Center who had been on dialysis for at least three months following the onset of acute kidney disease, were in the end-stage renal disease (ESRD) phase, and had a confirmed diagnosis of COVID-19 (based on reports from accredited laboratories of Mazandaran University of Medical Sciences or characteristic findings on chest CT scans). Finally, various demographic, clinical, and laboratory parameters were compared between deceased and surviving patients.
Results: A total of 64 hemodialysis patients with COVID-19 were examined, of whom 33 (51.6%) died during the study period. Compared with surviving patients, deceased patients had significantly higher levels of CRP, AST, and ALT (P < 0.05 for all comparisons). Logistic regression analysis identified male sex, elevated body mass index (BMI), diabetes, cardiovascular disease, elevated CRP and ALT levels, and greater than 50% lung involvement as predictive factors of mortality in hemodialysis patients with COVID-19.
Conclusion: Considering that liver function tests are an integral part of routine biochemical investigations, are available in even the simplest laboratories in both urban and rural settings, and are relatively inexpensive and well standardized, abnormalities in liver function tests may serve as cost-effective markers of disease severity. These tests could therefore be valuable tools for family physicians, particularly at the community level, in assessing the severity of complications in patients with chronic kidney disease, especially hemodialysis patients affected by COVID-19.
Type of Study: Research(Original) |
Subject:
Nephrology
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