Volume 21, Issue 2 (2-2012)
J Mazandaran Univ Med Sci 2012, 21(2): 140-144 |
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Mohammad S, Abbasi A, sHADBORESTAN A, Omidi M. Pathology examination of liver and kidney in diazinon exposed rat and role of L- carnitine. J Mazandaran Univ Med Sci 2012; 21 (2) :140-144
URL: http://jmums.mazums.ac.ir/article-1-2107-en.html
URL: http://jmums.mazums.ac.ir/article-1-2107-en.html
Abstract: (11893 Views)
Background and purpose: Diazinon, is the common name an organophosphorus pesticide (OP), used to control pest insects in soil, on ornamental plants, and on fruit and vegetable field crops. DZN induce oxidative stress leading to generation of free radicals and change in antioxidants system and caused pathological change in body.
The purpose of this study was to assess the protective effects of L-Carnitine against pathological change of kidney and liver induced by diazinon in rat
Materials and methods: In this study, used male Wistar rats in the range of 200 ± 250 gr (n =5). Animals were randomly divided into 9 groups and received chemicals for 4 weeks intraperitoneally. After necropsy, liver and kidneys of all animals were isolated and fixed in 10% buffered formalin. Using examples of common practices pathology tissue sections, 5 microns thick sections by microtome and prepared for staining with hematoxylin - eosin were prepared.
Results: in the liver of groups that diazinon had received, focal hepatic necrosis was created. Exposure also causes dilation of sinusoids in the liver parenchyma. Liver and kidney pathology in the groups receiving doses of 50mg / kg carnitine as a control group.in a dose 150mg / kg central venous distention was seen in the liver. in the groups of receiving diazinon and L - carnitine central venous inflammation, congestion and necrosis were evident. The dose 150 mg / kg inflammation persists, but necrosis was significantly reduced. The pathology of the kidney tissue in the groups receiving diazinon showed inflammation and congestion
Conclusion: This study showed thatdiazinonhas theability to induced liverdamage although damagetokidney tissue is lesser.It alsowas shown that L-carnitine indose-dependent manner is able to reduced diazinon induced damage
Type of Study: Research(Original) |
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