Volume 34, Issue 241 (1-2025)                   J Mazandaran Univ Med Sci 2025, 34(241): 89-97 | Back to browse issues page

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Shiroud Bakhshi K, Nahvi A, Lashtoo Aghaee B. Evaluating the Impact of Probiotics on Paediatric Constipation at Imam Sajjad Hospital, Ramsar. J Mazandaran Univ Med Sci 2025; 34 (241) :89-97
URL: http://jmums.mazums.ac.ir/article-1-21138-en.html
Abstract:   (567 Views)
Background and purpose: Constipation is a significant health issue among children, requiring prompt screening and early diagnosis due to its substantial contribution to disease burden. Probiotics, which colonize the bowel, are known to exert positive effects on the gut microbiota. While probiotics have been extensively studied in relation to various gastrointestinal disorders, there is limited research specifically addressing their efficacy in managing pediatric constipation. To address this gap, we designed a study to evaluate the impact of probiotics on the treatment of constipation in children attending the Imam Sajad hospital clinic in Ramsar, Iran.
Materials and methods: This double-blind clinical trial involved 90 children diagnosed with constipation, who were randomly assigned to either an intervention or a control group. For each child, a checklist was first completed, and all children received toilet training conducted by the researcher. The control group received standard treatment for constipation, which included 0.7-1.5 grams per kilogram of Polyethylene Glycol (PEG) powder (Pidrolox). The intervention group received the same standard treatment in addition to a probiotic supplement (Kidy Lact). The study duration was four weeks and all the patients were clinically examined at two and four weeks after the intervention. The primary assessment criteria included stool consistency, the frequency of incontinence episodes per week, the presence of abdominal pain, and painful bowel movements. Secondary evaluations focused on treatment success and any adverse effects, such as diarrhea and vomiting.
Results: After two weeks, no significant differences were observed between the intervention
and control groups regarding stool frequency, painful defecation, incontinence, and abdominal pain (P=0.30, P=0.85, P=0.53, and P=0.23, respectively). Furthermore, after four weeks, stool frequency and incontinence did not show significant differences between the two groups (P=0.22 and P=0.53, respectively). However, the frequency of painful bowel movements in the intervention group was significantly lower than in the control group (P=0.04).

Conclusion: Based on the findings of this study, adding probiotics to the standard treatment for functional constipation, such as Polyethylene Glycol powder, may be beneficial for children. To obtain more precise results, it is recommended that long-term studies be conducted using probiotics.

(Clinical Trials Registry Number: IRCT20230107057070N2)

 
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Type of Study: Research(Original) | Subject: children

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