Volume 35, Issue 249 (10-2025)
J Mazandaran Univ Med Sci 2025, 35(249): 108-113 |
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Parhiz J, Rahafard S, Montazeri M, Taneh S. Comparison of the effect of ceftriaxone versus ciprofloxacin treatment on Shigella dysentery in children referred to Taleghani Children's Hospital in Gorgan, 2024. J Mazandaran Univ Med Sci 2025; 35 (249) :108-113
URL: http://jmums.mazums.ac.ir/article-1-21360-en.html
URL: http://jmums.mazums.ac.ir/article-1-21360-en.html
Abstract: (378 Views)
Background and purpose: Diarrheal diseases are considered one of the serious health problems and major causes of mortality in children under 5 years of age. Considering the contradiction and difference in the effectiveness of antibiotics recommended in the treatment of dysentery, this study was conducted to compare the effect of ceftriaxone and ciprofloxacin in the treatment of acute Shigella hemorrhagic dysentery in children.
Materials and methods: This study was an interventional, randomized, parallel, single-blind clinical trial on 196 children aged 2-15 years with acute Shigella hemorrhagic dysentery at Taleghani Pediatric Hospital, Gorgan. After obtaining ethical approvals, patients were randomly assigned to one of two study groups (ceftriaxone or ciprofloxacin) using a block-based method. After 48 hours of treatment, the clinical symptoms, laboratory tests, and demographic variables of the patients were recorded and analyzed using a checklist
Results: Patients in the two groups had similar distributions in terms of gender, ethnicity, and age. The type of treatment (ceftriaxone or ciprofloxacin) had no effect on the length of hospitalization of children with acute bloody diarrhea referred to Taleghani Hospital in Gorgan (P=0.254). There was also no statistically significant difference between the proportion of children who recovered within 48 hours of treatment with ceftriaxone and ciprofloxacin (P=0.144) and the proportion of children whose stool cultures were negative on the fifth day of hospitalization (P=0.538).
Conclusion: According to the results of this study, the effect of antibiotic treatment in children with acute Shigella bloody diarrhea is not related to demographic factors (age, gender, ethnicity). Also, no difference was observed between the use of ciprofloxacin and ceftriaxone in the treatment of dysentery.
(Clinical Trials Registry Number: IRCT20231119060110N1)
Materials and methods: This study was an interventional, randomized, parallel, single-blind clinical trial on 196 children aged 2-15 years with acute Shigella hemorrhagic dysentery at Taleghani Pediatric Hospital, Gorgan. After obtaining ethical approvals, patients were randomly assigned to one of two study groups (ceftriaxone or ciprofloxacin) using a block-based method. After 48 hours of treatment, the clinical symptoms, laboratory tests, and demographic variables of the patients were recorded and analyzed using a checklist
Results: Patients in the two groups had similar distributions in terms of gender, ethnicity, and age. The type of treatment (ceftriaxone or ciprofloxacin) had no effect on the length of hospitalization of children with acute bloody diarrhea referred to Taleghani Hospital in Gorgan (P=0.254). There was also no statistically significant difference between the proportion of children who recovered within 48 hours of treatment with ceftriaxone and ciprofloxacin (P=0.144) and the proportion of children whose stool cultures were negative on the fifth day of hospitalization (P=0.538).
Conclusion: According to the results of this study, the effect of antibiotic treatment in children with acute Shigella bloody diarrhea is not related to demographic factors (age, gender, ethnicity). Also, no difference was observed between the use of ciprofloxacin and ceftriaxone in the treatment of dysentery.
(Clinical Trials Registry Number: IRCT20231119060110N1)
Type of Study: Brief Report |
Subject:
general practitioner
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