Volume 35, Issue 248 (9-2025)
J Mazandaran Univ Med Sci 2025, 35(248): 39-48 |
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Davoodi L, Davoodi A, Mofid Nakhae Z, Ghandi S, Talebi Moghaddam M. Clinical and Laboratory Evaluation of Patients with Infectious Endocarditis at Fatemeh Zahra Hospital, Sari. J Mazandaran Univ Med Sci 2025; 35 (248) :39-48
URL: http://jmums.mazums.ac.ir/article-1-21391-en.html
URL: http://jmums.mazums.ac.ir/article-1-21391-en.html
Abstract: (233 Views)
Background and purpose: Endocarditis is characterized by the proliferation of microorganisms in the endocardial layer of the heart. The diagnosis of infectious endocarditis relies on a combination of clinical signs, echocardiography, histological examination, and microbiological testing. This study aimed to evaluate the clinical and laboratory diagnostic features of patients with infectious endocarditis.
Materials and methods: In this cross-sectional study, 98 patients diagnosed with endocarditis were included. Demographic data (age and gender) and disease-related factors (history of injecting drug use, underlying conditions, symptoms, complications, and laboratory findings) were documented. Data were obtained from hospital records and analyzed using SPSS version 20.
Results: he averages age of the patients was 53.2 ± 19.9 years, with 59% male and 41% female. Fever was the most prevalent symptom. Among the patients, 11.2% had a history of injecting drug use. Additionally, 63% of the patients had artificial heart valves, with the mitral valve being the most commonly affected (39%). Blood cultures were negative in 67% of cases and positive in 33%. Staphylococcus aureus was the most frequently identified pathogen (41%). The in-hospital mortality rate was 7%, with a significant association between mortality and the type of valve involved (P = 0.01). The tricuspid valve was the most commonly affected in patients who injected drugs (45%) (P =0.001).
Conclusion: Symptoms such as fever, heart murmurs, the presence of artificial valves, and a history of injecting drug use are important clinical indicators of infectious endocarditis. For patients presenting with these features and relevant medical history, initial laboratory testing and echocardiography are essential for timely diagnosis and effective management.
Materials and methods: In this cross-sectional study, 98 patients diagnosed with endocarditis were included. Demographic data (age and gender) and disease-related factors (history of injecting drug use, underlying conditions, symptoms, complications, and laboratory findings) were documented. Data were obtained from hospital records and analyzed using SPSS version 20.
Results: he averages age of the patients was 53.2 ± 19.9 years, with 59% male and 41% female. Fever was the most prevalent symptom. Among the patients, 11.2% had a history of injecting drug use. Additionally, 63% of the patients had artificial heart valves, with the mitral valve being the most commonly affected (39%). Blood cultures were negative in 67% of cases and positive in 33%. Staphylococcus aureus was the most frequently identified pathogen (41%). The in-hospital mortality rate was 7%, with a significant association between mortality and the type of valve involved (P = 0.01). The tricuspid valve was the most commonly affected in patients who injected drugs (45%) (P =0.001).
Conclusion: Symptoms such as fever, heart murmurs, the presence of artificial valves, and a history of injecting drug use are important clinical indicators of infectious endocarditis. For patients presenting with these features and relevant medical history, initial laboratory testing and echocardiography are essential for timely diagnosis and effective management.
Type of Study: Research(Original) |
Subject:
Epidemiology
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