Volume 23, Issue 108 (1-2014)                   J Mazandaran Univ Med Sci 2014, 23(108): 30-39 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sedighi M, Noori–Ahmadabadi M, Rafieian-Kopaei M, Ebrahimpoor-Samani J, Shahinfard N. The effect of Rosa damascena Mill Hydro-alcoholic extract on the ileum contraction in rat . J Mazandaran Univ Med Sci. 2014; 23 (108) :30-39
URL: http://jmums.mazums.ac.ir/article-1-2147-en.html
Abstract:   (10616 Views)
Background and purpose: Rosa damascena Mill in Iranian folk medicine is used for treating digestive disorders. We assessed the antispasmodic effects of extract of the leaves of this plant on ileum contractions in Wistar rats possible mechanisms were investigated, too. Materials and methods: In this experimental study, 48 male Wistar rats (150-200 g) were divided randomly into six groups of eight members, including control group and the groups received extracts of Rosa damascena Mill, propranolol, naloxone, L-nitro-arginine methyl ester (L-NAME), and calcium chloride. To evaluate the effectiveness mechanisms, ileum was placed adjacent to antagonist drugs of β-adrenergic receptors, opioid and inhibitor of the synthesis of nitric oxide, and also under the influence of different doses of calcium chloride. The observed effects were recorded. Then, the percent changes were calculated. Statistical analysis was done using parametric tests of repeated measuring design, ANOVA and t tests. Results: Cumulative extract of Rosa damascena Mill (100, 500 and 1000 mg/k) decreased ileum contractions induced by KCl (P < 0.0001). Propranolol and naloxone significantly decreased the inhibitive effect of the extract on contractions induced by KCl (P < 0.0010), but L-NAME was ineffective. Also, calcium led to the contraction of depolarized tissue through KCI and this contractile effect decreased significantly by the cumulative concentration of Rosa damascena Mill (P < 0.0010). Conclusion: Extract of Rosa damascena Mill probably decreases ileum movements of the rat through stimulating the β-adrenergic and opioid receptors and voltage-dependent channels, and it may be used to treat digestive disorders.
Full-Text [PDF 283 kb]   (1951 Downloads)    
Type of Study: Research(Original) | Subject: physiology

Add your comments about this article : Your username or Email:

Send email to the article author

© 2018 All Rights Reserved | Journal of Mazandaran University of Medical Sciences

Designed & Developed by : Yektaweb