Volume 34, Issue 242 (2-2025)
J Mazandaran Univ Med Sci 2025, 34(242): 138-144 |
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Davoodi L, Halimi M A, Shirzad Ahoodashti M, Talebi Moghaddam M, Ghandi S. The Relationship Between COVID-19 and New-Onset Diabetes: Clinical Features, Risk Factors, and Outcomes. J Mazandaran Univ Med Sci 2025; 34 (242) :138-144
URL: http://jmums.mazums.ac.ir/article-1-21491-en.html
URL: http://jmums.mazums.ac.ir/article-1-21491-en.html
Lotfollah Davoodi 
, Mohammad Amin Halimi , Mahboobeh Shirzad Ahoodashti , Maryam Talebi Moghaddam , Sara Ghandi
, Mohammad Amin Halimi , Mahboobeh Shirzad Ahoodashti , Maryam Talebi Moghaddam , Sara Ghandi
Abstract: (343 Views)
Background and purpose: COVID-19, caused by the SARS-CoV-2 virus, primarily targets the respiratory system but can also impair other organs, including the pancreas, potentially increasing the risk of new-onset diabetes. Emerging evidence highlights that some patients recovering from COVID-19 face an elevated risk of developing diabetes, underscoring the need for further investigation. This study aims to determine the prevalence and identify potential risk factors for new-onset diabetes in patients recovering from COVID-19.
Materials and methods: This cohort study involved 933 patients with confirmed COVID-19, all of whom were admitted to Qaemshahr Razi Hospital and had no prior diabetes diagnosis. Patients were stratified based on the severity of their COVID-19 infection and followed for three months post-discharge. Fasting plasma glucose (FPG) and HbA1c tests were performed to diagnose diabetes. Detailed demographic data, clinical indicators, and inflammatory markers, including CRP, LDH, and D-dimer, were recorded for analysis. Data analysis was conducted using SPSS software, and appropriate statistical tests were applied to compare variables across patient groups.
Results: The findings revealed that patients with new-onset diabetes were significantly older, had higher body mass indices, and had a positive family history of diabetes. Elevated levels of inflammatory markers, such as CRP and LDH, were observed in these patients. Moreover, the severity of COVID-19 symptoms, including shortness of breath and fever, was significantly associated with the development of diabetes.
Conclusion: This study demonstrates a clear association between COVID-19 and an increased risk of diabetes, particularly in patients with severe disease manifestations. Post-recovery blood glucose monitoring is strongly recommended, and timely management should be prioritized for patients diagnosed with diabetes.
Materials and methods: This cohort study involved 933 patients with confirmed COVID-19, all of whom were admitted to Qaemshahr Razi Hospital and had no prior diabetes diagnosis. Patients were stratified based on the severity of their COVID-19 infection and followed for three months post-discharge. Fasting plasma glucose (FPG) and HbA1c tests were performed to diagnose diabetes. Detailed demographic data, clinical indicators, and inflammatory markers, including CRP, LDH, and D-dimer, were recorded for analysis. Data analysis was conducted using SPSS software, and appropriate statistical tests were applied to compare variables across patient groups.
Results: The findings revealed that patients with new-onset diabetes were significantly older, had higher body mass indices, and had a positive family history of diabetes. Elevated levels of inflammatory markers, such as CRP and LDH, were observed in these patients. Moreover, the severity of COVID-19 symptoms, including shortness of breath and fever, was significantly associated with the development of diabetes.
Conclusion: This study demonstrates a clear association between COVID-19 and an increased risk of diabetes, particularly in patients with severe disease manifestations. Post-recovery blood glucose monitoring is strongly recommended, and timely management should be prioritized for patients diagnosed with diabetes.
Type of Study: Brief Report |
Subject:
infection
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