Volume 35, Issue 248 (9-2025)
J Mazandaran Univ Med Sci 2025, 35(248): 139-149 |
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Nandoust kenari S, Mohamadynejad P, Moghanibashi M, Bagheri A, Rouhi L. A Review of the Functions and Molecular Mechanisms of the Long Non-Coding RNA G2E3-AS1 in Cancer. J Mazandaran Univ Med Sci 2025; 35 (248) :139-149
URL: http://jmums.mazums.ac.ir/article-1-21859-en.html
URL: http://jmums.mazums.ac.ir/article-1-21859-en.html
Shahrbanoo Nandoust kenari 
, Parisa Mohamadynejad , Mehdi Moghanibashi , Abouzar Bagheri , Leila Rouhi
, Parisa Mohamadynejad , Mehdi Moghanibashi , Abouzar Bagheri , Leila Rouhi
Abstract: (16 Views)
The role of non-coding RNAs in regulating gene expression has introduced a new dimension of gene regulation in eukaryotic cells. Long non-coding RNAs (lncRNAs) can modulate chromatin structure and function, regulate gene expression at both the transcriptional and post-transcriptional levels, and influence RNA splicing, stability, and translation. Thus, lncRNAs participate in various biological processes, including cell proliferation, programmed cell death, signal transduction, and cell differentiation. For this reason, they have attracted considerable interest in the context of carcinogenesis. In this study, with the aim of providing a comprehensive overview of the role and function of the long non-coding RNA (lncRNA) G2E3-AS1 in the pathogenesis and progression of human cancers, relevant articles published between 2017 and 2025 were reviewed. Emerging evidence has revealed diverse roles of G2E3-AS1 in various malignancies. Increased expression of lncRNA G2E3-AS1 has been reported in multiple cancers, and its ability to effectively distinguish between tumor and normal tissues demonstrates significant diagnostic potential. LncRNA G2E3-AS1 is implicated in a broad range of tumor-related processes, including cell proliferation, apoptosis, invasion, migration, and metastasis. Moreover, lncRNA G2E3-AS1 can function as a competing endogenous RNA and interact with proteins to regulate key cancer-related pathways. By investigating the molecular mechanisms and pathways associated with lncRNA G2E3-AS1, as well as its relationship with the clinical and prognostic features of cancers, this study suggests that lncRNA G2E3-AS1 may serve as a promising biomarker and therapeutic target in oncology.
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