sajedi F, Motavasselian M, Boroumand Rezazadeh M, mahjoub F. Investigating the Etiology and Treatment of Endometriosis: Perspectives from Persian Medicine and Modern Medicine. J Mazandaran Univ Med Sci 2025; 35 (249) :121-134 URL: http://jmums.mazums.ac.ir/article-1-21998-en.html
Endometriosis is a common gynecological disorder characterized by the growth of endometrial tissue outside the uterus. Due to theinadequacy of current treatments, complementary medicine is increasing today. The aim of this study is to conduct a comparative study of endometriosis from the perspectives of Persian and modern medicine to provide a better understanding of the disease and enable the development of more effective integrated management strategies for patients.This study is a narrative review that investigates the symptoms, etiology, pathophysiology, and treatment of endometriosis from the perspectives of Persian Medicine and modern medicine. To achieve this, a comprehensive literature search was performed based on relevant keywords in major databases, and authoritative sources in Persian Medicine. The extracted data were classified and comparatively evaluated to identify similarities and differences between the two medical paradigms.Pain, infertility and menstrual disorders are the most common symptoms of endometriosis, which in Persian Medicine can occur in the context of uterine dysfunction such as uterine dystemperament or various types of uterine tumefactions, including warm, melancholic, or phlegmatic. A study of risk and protective factors in endometriosis shows that lifestyle modification plays an effective role in preventing and treating this condition. Several medicinal herbs have been recommended in Persian Medicine sources for treating different types of uterine tumefactions based on their underlying etiology. Modern studies have demonstrated that these herbs exhibit antioxidant, anti-inflammatory, anti-angiogenic effects, and suppress the proliferation and migration of endometrial cells in endometriosis.By investigating the symptoms and complications of endometriosis and comparing them with Persian medical sources, it seems that a spectrum of disorders centered on uterine dystemperament and uterine tumefactions have the greatest correspondence with endometriosis. Further studies are recommended to investigate integrated approaches in diagnostic and therapeutic dimensions.