Volume 35, Issue 250 (11-2025)
J Mazandaran Univ Med Sci 2025, 35(250): 185-191 |
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Malek Bagali F, Hanifezadeh H, Azghani P, Amani F, karami C. Investigation of Serum Levels of Epstein-Barr virus VCA-IgG Antibodies in Gastric Cancer Patients in Ardabil, NorthWest Iran, during 2023-2024: A Brief Report. J Mazandaran Univ Med Sci 2025; 35 (250) :185-191
URL: http://jmums.mazums.ac.ir/article-1-22008-en.html
URL: http://jmums.mazums.ac.ir/article-1-22008-en.html
Abstract: (36 Views)
Background and purpose: Gastric cancer (GC) is one of the most common cancers worldwide. Many environmental factors have been identified as potential risk factors for gastric cancer. However, Epstein-Barr virus (EBV) has been suggested to indirectly contribute to GC pathogenesis. Due to limited information about the etiologic role of EBV in gastric cancer, in this cross-sectional study, the serum levels of IgG antibodies against the viral capsid antigen (VCA-IgG) of EBV in GC patients in Ardabil city were measured.
Materials and methods: This cross-sectional study included a total of 184 participants, 92 gastric cancer patients, and 92 healthy individuals as the control group. Demographic and pathological data were recorded, and Serum samples were collected to measure the VCA IgG antibody levels.
Results: Among the 184 participants, 92 had gastric cancer, and 92 had chronic gastritis as the control group. In total, 108 (7.58%) were male and 76 (3.41%) were female. In terms of blood group, the most common type was A (44%) and the least common was B (6.7%) in both the patient and control groups. Serum VCA-IgG testing showed that among gastric cancer patients, 37 patients were positive and 55 patients were negative, while in the control group, 41 patients were positive and 51 patients were negative (p=0.02). Helicobacter pylori testing showed that 105 participants were positive and 79 were negative, and there was no significant association between age, gender, and H. pylori infection and VCA-IgG antibody serostatus (p>0.05). A significant association was observed between blood group and VCA-IgG seropositivity (p=0.02).
Conclusion: Considering that the level of VCA-IgG is present in both control and patient groups, it indicates that these individuals had previous contact with EBV, but for further evaluation of the association between the virus and gastric cancer, additional studies with large-scale samples are required.
Materials and methods: This cross-sectional study included a total of 184 participants, 92 gastric cancer patients, and 92 healthy individuals as the control group. Demographic and pathological data were recorded, and Serum samples were collected to measure the VCA IgG antibody levels.
Results: Among the 184 participants, 92 had gastric cancer, and 92 had chronic gastritis as the control group. In total, 108 (7.58%) were male and 76 (3.41%) were female. In terms of blood group, the most common type was A (44%) and the least common was B (6.7%) in both the patient and control groups. Serum VCA-IgG testing showed that among gastric cancer patients, 37 patients were positive and 55 patients were negative, while in the control group, 41 patients were positive and 51 patients were negative (p=0.02). Helicobacter pylori testing showed that 105 participants were positive and 79 were negative, and there was no significant association between age, gender, and H. pylori infection and VCA-IgG antibody serostatus (p>0.05). A significant association was observed between blood group and VCA-IgG seropositivity (p=0.02).
Conclusion: Considering that the level of VCA-IgG is present in both control and patient groups, it indicates that these individuals had previous contact with EBV, but for further evaluation of the association between the virus and gastric cancer, additional studies with large-scale samples are required.
Keywords: Gastric Cancer (GC), Epstein-Barr Virus (EBV), Viral Capsid Antigen (VCA), gastritis, Ardabil
Type of Study: Brief Report |
Subject:
Microbiology
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