Volume 35, Issue 248 (9-2025)
J Mazandaran Univ Med Sci 2025, 35(248): 5-16 |
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mahboudi H, lotfi M, sadeghi ghadi Z. Evaluation of the Anticancer Effect of a Niosomal Suspension of Aripiprazole against the HT-29 Cell Line. J Mazandaran Univ Med Sci 2025; 35 (248) :5-16
URL: http://jmums.mazums.ac.ir/article-1-22034-en.html
URL: http://jmums.mazums.ac.ir/article-1-22034-en.html
Abstract: (19 Views)
Background and purpose: Cancer is one of the leading causes of death worldwide. One of the emerging approaches in therapeutic studies on various cancers is the use of non-specific drugs in cancer treatment. Aripiprazole is a novel antipsychotic drug whose anti-cancer effects have been demonstrated in previous studies. Due to its low solubility, and in order to enhance the anticancer efficacy of aripiprazole while minimizing drug toxicity, this study developed a niosomal system of aripiprazole and investigated its anticancer efficacy.
Materials and methods: In this experimental study, aripiprazole niosomes were prepared using the thin-film hydration method. The physicochemical properties of the system, including particle size, size distribution, and aripiprazole loading, were measured. Transmission electron microscopy was performed to examine the morphology of the niosomes. Subsequently, the cytotoxic effects of the prepared niosomes on HT-29 cancer cells and normal fibroblast cells were evaluated using the MTT cell viability assay.
Results: The particle size of the niosomes was 973.5 ± 48.8 nm, the particle size dispersion index (PDI) was 0.68±0.11, and the zeta potential was −67.68 ± 2.47 mV. The aripiprazole loading was 61.64%, and spherical niosomes were observed in the transmission electron microscope images. The results demonstrated that the cytotoxicity of aripiprazole niosomes was higher than that of pure aripiprazole in cancer cells, while they induced minimal toxicity in normal cells.
Conclusion: The results of this study showed that the greatest growth inhibition in HT-29 cells was achieved with aripiprazole niosomes. Moreover, aripiprazole niosomes exhibited lower toxicity toward normal cells compared to pure aripiprazole. Overall, these findings indicate that the anticancer efficacy of aripiprazole is enhanced through niosomal delivery.
Materials and methods: In this experimental study, aripiprazole niosomes were prepared using the thin-film hydration method. The physicochemical properties of the system, including particle size, size distribution, and aripiprazole loading, were measured. Transmission electron microscopy was performed to examine the morphology of the niosomes. Subsequently, the cytotoxic effects of the prepared niosomes on HT-29 cancer cells and normal fibroblast cells were evaluated using the MTT cell viability assay.
Results: The particle size of the niosomes was 973.5 ± 48.8 nm, the particle size dispersion index (PDI) was 0.68±0.11, and the zeta potential was −67.68 ± 2.47 mV. The aripiprazole loading was 61.64%, and spherical niosomes were observed in the transmission electron microscope images. The results demonstrated that the cytotoxicity of aripiprazole niosomes was higher than that of pure aripiprazole in cancer cells, while they induced minimal toxicity in normal cells.
Conclusion: The results of this study showed that the greatest growth inhibition in HT-29 cells was achieved with aripiprazole niosomes. Moreover, aripiprazole niosomes exhibited lower toxicity toward normal cells compared to pure aripiprazole. Overall, these findings indicate that the anticancer efficacy of aripiprazole is enhanced through niosomal delivery.
Type of Study: Research(Original) |
Subject:
Pharmaceutics
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