Volume 35, Issue 251 (12-2025)
J Mazandaran Univ Med Sci 2025, 35(251): 75-88 |
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Ghoreishi A, ghazizadeh Khosroshahi T, Sadeghi Hokmabadi E, Aghamiri S H, Soleymani R, Malekmahmoudi G, et al . Diagnostic Value of Transcranial Sonography in Parkinson’s Disease Among Iranian Patients. J Mazandaran Univ Med Sci 2025; 35 (251) :75-88
URL: http://jmums.mazums.ac.ir/article-1-22041-en.html
URL: http://jmums.mazums.ac.ir/article-1-22041-en.html
Abdoreza Ghoreishi 
, Taher Ghazizadeh Khosroshahi , Elyar Sadeghi Hokmabadi , Seyed Hossein Aghamiri , Reyhane Soleymani , Ghazal Malekmahmoudi , Ghazaleh Bahrami , Mahdi Ahani
, Taher Ghazizadeh Khosroshahi , Elyar Sadeghi Hokmabadi , Seyed Hossein Aghamiri , Reyhane Soleymani , Ghazal Malekmahmoudi , Ghazaleh Bahrami , Mahdi Ahani
Abstract: (22 Views)
Background and purpose: Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder after Alzheimer's disease. Diagnosing Parkinson’s disease at the preclinical stage, and distinguishing it from other movement disorders in their early phases, remains challenging. Substantia nigra echogenicity was assessed using transcranial sonography, and an optimal diagnostic cutoff value was identified.
Materials and methods: In this case–control study conducted at Valiasr Hospital, 34 patients with Parkinson’s disease (aged >40 years) and 34 age-matched healthy controls were enrolled. All participants underwent transcranial sonography performed by a specialist, and the substantia nigra echogenic area was bilaterally measured by a sonographer using standardized settings. Data were analyzed using the Mann–Whitney U test and ROC curve analysis to compare groups and to establish the optimal diagnostic cutoff.
Results: The mean age was 62.3 ± 7.4 years in the PD group and 61.8 ± 6.9 years in controls
(P= 0.72), with no significant difference in sex distribution between the groups (P = 0.65). The mean bilateral substantia nigra echogenic area was 29.26 ± 6.77 mm² in the case group and 10.00 ± 3.96 mm² in the control group (P< 0.001). The identified cutoff value for the mean bilateral substantia nigra echogenic area was 20.00 mm², with a sensitivity of 100% and a specificity of 97% (P< 0.001).
Conclusion: Transcranial sonography (TCS), with a sensitivity of 100% and a specificity of 97% at a threshold of 20 mm², is an accurate and noninvasive method for the diagnosis of Parkinson’s disease and may help address the limitations of MRI in differentiating Parkinson’s disease from atypical parkinsonian syndromes (AP). In patients with Parkinson’s disease, substantia nigra echogenicity increases, whereas its measured area decreases. Moreover, the 20 mm² threshold identified in the Iranian population is consistent with previous studies and underscores the need for further research in this field.
Materials and methods: In this case–control study conducted at Valiasr Hospital, 34 patients with Parkinson’s disease (aged >40 years) and 34 age-matched healthy controls were enrolled. All participants underwent transcranial sonography performed by a specialist, and the substantia nigra echogenic area was bilaterally measured by a sonographer using standardized settings. Data were analyzed using the Mann–Whitney U test and ROC curve analysis to compare groups and to establish the optimal diagnostic cutoff.
Results: The mean age was 62.3 ± 7.4 years in the PD group and 61.8 ± 6.9 years in controls
(P= 0.72), with no significant difference in sex distribution between the groups (P = 0.65). The mean bilateral substantia nigra echogenic area was 29.26 ± 6.77 mm² in the case group and 10.00 ± 3.96 mm² in the control group (P< 0.001). The identified cutoff value for the mean bilateral substantia nigra echogenic area was 20.00 mm², with a sensitivity of 100% and a specificity of 97% (P< 0.001).
Conclusion: Transcranial sonography (TCS), with a sensitivity of 100% and a specificity of 97% at a threshold of 20 mm², is an accurate and noninvasive method for the diagnosis of Parkinson’s disease and may help address the limitations of MRI in differentiating Parkinson’s disease from atypical parkinsonian syndromes (AP). In patients with Parkinson’s disease, substantia nigra echogenicity increases, whereas its measured area decreases. Moreover, the 20 mm² threshold identified in the Iranian population is consistent with previous studies and underscores the need for further research in this field.
Type of Study: Research(Original) |
Subject:
Neurology
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