Volume 35, Issue 251 (12-2025)
J Mazandaran Univ Med Sci 2025, 35(251): 65-74 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Montazer F, Abbasi M A, Eshaqian E. Prevalence of Preneoplastic Gastric Lesions in Pathology Samples of Dyspeptic Patients Undergoing Endoscopy at Firoozabadi Hospital (2018–2022). J Mazandaran Univ Med Sci 2025; 35 (251) :65-74
URL: http://jmums.mazums.ac.ir/article-1-22087-en.html
URL: http://jmums.mazums.ac.ir/article-1-22087-en.html
Abstract: (22 Views)
Background and purpose: Gastric cancer is one of the most common malignancies and a major cause of cancer-related mortality worldwide, including Iran. Gastric preneoplastic lesions (including atrophy, intestinal metaplasia, and dysplasia) play an important role in the progression to gastric adenocarcinoma. The aim of this study was to determine the prevalence of these preneoplastic lesions in patients with dyspeptic symptoms referred to Firoozabadi Hospital during 2018–2022. The findings are intended to provide data to support gastric cancer prevention strategies.
Materials and methods: This retrospective cross-sectional study was conducted among 327 dyspeptic patients who underwent endoscopy at Firoozabadi Hospital. Inclusion criteria included age over 18 years, presence of dyspeptic symptoms, gastric mucosal biopsy, and complete medical records. Patients with a diagnosis of gastric cancer, history of gastric surgery, pregnancy, or unwillingness to participate were excluded. Preneoplastic lesions and Helicobacter pylori infection were evaluated based on the Updated Sydney System in pathology reports, and data were analyzed using SPSS version 26.
Results: Of 327 patients (54.7% male, 45.3% female; mean age 51.63 ± 19.08 years), 82.6% (270 patients) had H. pylori infection (p=0.006). Intestinal metaplasia was observed in 21.4% (p<0.001), dysplasia in 1.8% (p=0.228), and gastric atrophy in 0.61% (p=1.00). Peptic ulcers (20%; p<0.001), acute inflammation (71.6%; p<0.001), and chronic inflammation (22%; p=0.706) were reported. Intestinal metaplasia was significantly associated with H. pylori (p=0.01) and age (p=0.001).
Conclusion: The high prevalence of Helicobacter pylori infection, acute inflammation, and intestinal metaplasia in dyspeptic patients underscores the necessity of screening and treatment of this infection to prevent gastric cancer in Iran. Early diagnosis and timely intervention can help prevent the progression of preneoplastic lesions.
Materials and methods: This retrospective cross-sectional study was conducted among 327 dyspeptic patients who underwent endoscopy at Firoozabadi Hospital. Inclusion criteria included age over 18 years, presence of dyspeptic symptoms, gastric mucosal biopsy, and complete medical records. Patients with a diagnosis of gastric cancer, history of gastric surgery, pregnancy, or unwillingness to participate were excluded. Preneoplastic lesions and Helicobacter pylori infection were evaluated based on the Updated Sydney System in pathology reports, and data were analyzed using SPSS version 26.
Results: Of 327 patients (54.7% male, 45.3% female; mean age 51.63 ± 19.08 years), 82.6% (270 patients) had H. pylori infection (p=0.006). Intestinal metaplasia was observed in 21.4% (p<0.001), dysplasia in 1.8% (p=0.228), and gastric atrophy in 0.61% (p=1.00). Peptic ulcers (20%; p<0.001), acute inflammation (71.6%; p<0.001), and chronic inflammation (22%; p=0.706) were reported. Intestinal metaplasia was significantly associated with H. pylori (p=0.01) and age (p=0.001).
Conclusion: The high prevalence of Helicobacter pylori infection, acute inflammation, and intestinal metaplasia in dyspeptic patients underscores the necessity of screening and treatment of this infection to prevent gastric cancer in Iran. Early diagnosis and timely intervention can help prevent the progression of preneoplastic lesions.
Type of Study: Research(Original) |
Subject:
Pathology
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Articles Copyright © The Author(s). Owned by Mazandaran University of Medical Sciences.
Contact Us
Address: Journal Office, Building No. 2, Mazandaran University of Medical Sciences, Moallem Square, Sari.Tel: +98 (011)34484874 Postal code: 48175-866 E-Mail: jmums@mazums.ac.ir Telefax: +98 (011)33262679
