Volume 36, Issue 255 (3-2026)
J Mazandaran Univ Med Sci 2026, 36(255): 4-11 |
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Khodabakhsh E, Ghaffari Hamedani S M M, Asadpour-sorkhkolaee H, Shirzad M, Jamali A. Investigating the Effect of Lactulose on the Improvement of Ileus After Abdominal Surgery: A Clinical Trial. J Mazandaran Univ Med Sci 2026; 36 (255) :4-11
URL: http://jmums.mazums.ac.ir/article-1-22221-en.html
URL: http://jmums.mazums.ac.ir/article-1-22221-en.html
Elmira Khodabakhsh 
, Seyyed Muhammad Mehdi Ghaffari Hamedani , Hodeise Asadpour-sorkhkolaee , Maliheh Shirzad , Amirhossein Jamali
, Seyyed Muhammad Mehdi Ghaffari Hamedani , Hodeise Asadpour-sorkhkolaee , Maliheh Shirzad , Amirhossein Jamali
Abstract: (323 Views)
Background and purpose: Ileus is one of the most common complications following abdominal surgery, resulting from impaired bowel motility and affecting nearly 50% of patients undergoing major abdominal procedures and 25% of those undergoing colorectal surgery. Despite advances in management, more effective treatments are still needed. This study aimed to evaluate the effect of lactulose on postoperative ileus.
Materials and methods: In this randomized clinical trial, 60 patients undergoing abdominal surgery via midline incision were allocated to a control group, which received routine postoperative care without lactulose, and an intervention group, which received lactulose syrup 10 cc every 8 hours after surgery. Demographic and clinical data, along with a checklist of recovery criteria, were collected. The effect of lactulose on bowel function at 12, 24, and 36 hours after surgery was assessed using statistical analyses in SPSS version 21.
Results: A total of 60 patients were studied, including 14 men and 16 women in the intervention group with a mean age of 54.40 years, and 18 men and 12 women in the control group with a mean age of 53.63 years (P > 0.05). Significant differences were observed between the intervention and control groups in the passage of gas and stool, indicating faster recovery in the intervention group (P = 0.0), whereas the difference in length of hospital stay was not statistically significant (P = 1.0). Factors such as the presence of anastomosis (P = 0.006), duration of surgery, and previous surgical history (P = 0.0) had a significant impact on bowel recovery.
Conclusion: The findings of this study indicate that postoperative administration of lactulose syrup plays an important role in improving ileus after abdominal surgery. In addition, anastomosis, prolonged operative time, previous surgical history, and underlying diseases significantly contribute to the development of postoperative ileus.
Materials and methods: In this randomized clinical trial, 60 patients undergoing abdominal surgery via midline incision were allocated to a control group, which received routine postoperative care without lactulose, and an intervention group, which received lactulose syrup 10 cc every 8 hours after surgery. Demographic and clinical data, along with a checklist of recovery criteria, were collected. The effect of lactulose on bowel function at 12, 24, and 36 hours after surgery was assessed using statistical analyses in SPSS version 21.
Results: A total of 60 patients were studied, including 14 men and 16 women in the intervention group with a mean age of 54.40 years, and 18 men and 12 women in the control group with a mean age of 53.63 years (P > 0.05). Significant differences were observed between the intervention and control groups in the passage of gas and stool, indicating faster recovery in the intervention group (P = 0.0), whereas the difference in length of hospital stay was not statistically significant (P = 1.0). Factors such as the presence of anastomosis (P = 0.006), duration of surgery, and previous surgical history (P = 0.0) had a significant impact on bowel recovery.
Conclusion: The findings of this study indicate that postoperative administration of lactulose syrup plays an important role in improving ileus after abdominal surgery. In addition, anastomosis, prolonged operative time, previous surgical history, and underlying diseases significantly contribute to the development of postoperative ileus.
Type of Study: Research(Original) |
Subject:
Colorectal Surgery
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