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Background and purpose: Cataract is an important vision problem in the elderly peoples and imposes huge costs on health services in countries. Increasing the level of free radicals in the body is one of the major factors in the incidence of age-related cataract. This study was conducted to measure plasma level of malondialdehyde (MDA) as plasma free radical index and plasma antioxidant levels in age-related cataract patients and compare with a control group. Materials and methods: This study was done on 61 patients as a case group and 39 healthy people by descriptive case-control study. After history obtaining, 5 ml of blood was taken from each individual and then plasma was frozen. MDA was measured by TBA reagent and Ferric Reducing Ability of Plasma (FRAP) Method was performed to assay total plasma antioxidant capacity. Results: The results of this study showed that the total plasma antioxidant capacity in cataract patients was lower than healthy people and plasma MDA level as plasma free radical index in cataract patients was significantly higher than healthy people (P < 0.05). Conclusion: Based on our results, it can be concluded that the antioxidant deficiency and increasing free radicals can be effective on age-related cataract.

Keywords: Free radical, antioxidant, age-related cataract, malondialdehyde, ferric reducing ability of plasma

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