Volume 35, Issue 254 (3-2026)
J Mazandaran Univ Med Sci 2026, 35(254): 26-38 |
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Aliasghari Jelodar S, Khosravi Largani S, Ghanbari-Niaki A. Effects of Aqueous Extract of Rosa canina L. Consumption and Aerobic Exercise on Liver Enzymes and Inflammatory Markers in Male Rats with D-Galactose-Induced Non-Alcoholic Fatty Liver Disease. J Mazandaran Univ Med Sci 2026; 35 (254) :26-38
URL: http://jmums.mazums.ac.ir/article-1-22596-en.html
URL: http://jmums.mazums.ac.ir/article-1-22596-en.html
Abstract: (433 Views)
Background and purpose: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disorder associated with inflammation, oxidative stress, and elevated liver enzymes. The aim of this study was to investigate the independent and combined effects of aerobic training and the aqueous extract of Rosa canina flowers on enzymatic and inflammatory markers in the liver tissue of D-galactose-induced male rats.
Materials and methods: In this experimental study, 45 male Wistar rats were randomly assigned to five equal groups (n= 9 per group): control, D-galactose, training + D-galactose, Rosa canina + D-galactose, and training + Rosa canina + D-galactose. NAFLD was induced by oral administration of D-galactose. The animals received D-galactose solution and Rosa canina flower extract via oral gavage five days per week throughout the intervention period. The aerobic training protocol consisted of eight weeks of progressive treadmill running. At the end of the intervention, rats were sacrificed under appropriate anaesthesia, and liver tissue samples were harvested for biochemical analyses. Hepatic enzyme levels and inflammatory markers were measured using standard laboratory methods. Statistical analyses were performed using one-way analysis of variance (ANOVA), followed by Tukey’s post hoc test for multiple comparisons. A P value < 0.05 was considered statistically significant.
Results: One-way ANOVA revealed that D-galactose administration significantly increased serum levels of ALT, AST, ALP, GGT, and LDH compared with the control group (P = 0.000). Aerobic training alone resulted in non-significant reductions in ALT (P= 0.987), AST (P= 0.099), GGT (P= 0.053), and LDH (P = 0.965), whereas ALP levels were significantly decreased (P= 0.004). Administration of Rosa canina extract alone significantly reduced all evaluated markers, including ALT (P = 0.000), AST (P = 0.014), ALP (P = 0.001), GGT (P= 0.000), and LDH (P= 0.009), compared with the D-galactose group. Furthermore, the combination of aerobic training and Rosa canina extract demonstrated the greatest hepatoprotective effect. ALT and AST levels returned to values comparable to those of the control group (ALT: P = 0.694; AST: P = 0.981), and ALP, GGT, and LDH levels were significantly reduced compared with the D-galactose group (ALP: P= 0.000; GGT: P= 0.016; LDH: P= 0.017).
Conclusion: The combination of aerobic training and Rosa canina flower extract exerted a synergistic hepatoprotective effect and may represent a promising non-pharmacological approach for the prevention or management of non-alcoholic fatty liver disease (NAFLD).
Materials and methods: In this experimental study, 45 male Wistar rats were randomly assigned to five equal groups (n= 9 per group): control, D-galactose, training + D-galactose, Rosa canina + D-galactose, and training + Rosa canina + D-galactose. NAFLD was induced by oral administration of D-galactose. The animals received D-galactose solution and Rosa canina flower extract via oral gavage five days per week throughout the intervention period. The aerobic training protocol consisted of eight weeks of progressive treadmill running. At the end of the intervention, rats were sacrificed under appropriate anaesthesia, and liver tissue samples were harvested for biochemical analyses. Hepatic enzyme levels and inflammatory markers were measured using standard laboratory methods. Statistical analyses were performed using one-way analysis of variance (ANOVA), followed by Tukey’s post hoc test for multiple comparisons. A P value < 0.05 was considered statistically significant.
Results: One-way ANOVA revealed that D-galactose administration significantly increased serum levels of ALT, AST, ALP, GGT, and LDH compared with the control group (P = 0.000). Aerobic training alone resulted in non-significant reductions in ALT (P= 0.987), AST (P= 0.099), GGT (P= 0.053), and LDH (P = 0.965), whereas ALP levels were significantly decreased (P= 0.004). Administration of Rosa canina extract alone significantly reduced all evaluated markers, including ALT (P = 0.000), AST (P = 0.014), ALP (P = 0.001), GGT (P= 0.000), and LDH (P= 0.009), compared with the D-galactose group. Furthermore, the combination of aerobic training and Rosa canina extract demonstrated the greatest hepatoprotective effect. ALT and AST levels returned to values comparable to those of the control group (ALT: P = 0.694; AST: P = 0.981), and ALP, GGT, and LDH levels were significantly reduced compared with the D-galactose group (ALP: P= 0.000; GGT: P= 0.016; LDH: P= 0.017).
Conclusion: The combination of aerobic training and Rosa canina flower extract exerted a synergistic hepatoprotective effect and may represent a promising non-pharmacological approach for the prevention or management of non-alcoholic fatty liver disease (NAFLD).
Type of Study: Research(Original) |
Subject:
Sport Physiology
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