Volume 36, Issue 258 (7-2026)
J Mazandaran Univ Med Sci 2026, 36(258): 125-131 |
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Nasiri Formi E, Tabatabaei Aghda S A, Azizi S, Siahposht-Khachaki A, Darayee M, Ebrahimnejad P. Comparison of the Effects of Abukhalsa (Arnebia euchroma) Ointment and Silver Nanoparticle-Containing Mupirocin Ointment on Macroscopic and Histopathological Changes During Burn and Surgical Wound Healing in Rats. J Mazandaran Univ Med Sci 2026; 36 (258) :125-131
URL: http://jmums.mazums.ac.ir/article-1-22894-en.html
URL: http://jmums.mazums.ac.ir/article-1-22894-en.html
Ebrahim Nasiri Formi 
, Seyyed Abolfazl Tabatabaei Aghda , Soheil Azizi , Ali Siahposht-Khachaki , Masood Darayee , Pedram Ebrahimnejad
, Seyyed Abolfazl Tabatabaei Aghda , Soheil Azizi , Ali Siahposht-Khachaki , Masood Darayee , Pedram Ebrahimnejad
Abstract: (9 Views)
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Materials and methods: In this experimental study, 72 male Wistar rats were divided into 12 groups (seven burn wound groups and five surgical wound groups). The healing process was evaluated by measuring wound area on days 3, 7, 14, and 21, together with qualitative histopathological evaluation using haematoxylin and eosin (H&E) staining on days 7 and 21 post-injury.
Results: In the burn wound model, no significant differences were observed on day 3; however, differences between the treatment groups became highly significant from day 7 onwards. By day 21, the Arnebia euchroma (2% and 5%) and nano-formulation (2% and 5%) treatment groups achieved complete wound healing, whereas the silver sulfadiazine group demonstrated the lowest efficacy. In the surgical wound model, all groups achieved complete healing by day 21, with the 2% nano-formulation group exhibiting the fastest healing rate. However, histopathological evaluation performed on day 21 revealed that the silver sulfadiazine, mupirocin, and 5% Arnebia euchroma groups exhibited greater collagen density and more organised collagen fibre orientation, indicating superior tissue quality, whereas tissue in the 2% nano-formulation group appeared less mature.
Conclusion: The efficacy of wound treatment depends on the wound type. Both the nano-formulation and the herbal ointment demonstrated superior efficacy in the treatment of burn wounds. In surgical wounds, a trade-off was observed between the rate of healing and the quality of the regenerated tissue, suggesting that faster healing does not necessarily lead to superior tissue regeneration.
Materials and methods: In this experimental study, 72 male Wistar rats were divided into 12 groups (seven burn wound groups and five surgical wound groups). The healing process was evaluated by measuring wound area on days 3, 7, 14, and 21, together with qualitative histopathological evaluation using haematoxylin and eosin (H&E) staining on days 7 and 21 post-injury.
Results: In the burn wound model, no significant differences were observed on day 3; however, differences between the treatment groups became highly significant from day 7 onwards. By day 21, the Arnebia euchroma (2% and 5%) and nano-formulation (2% and 5%) treatment groups achieved complete wound healing, whereas the silver sulfadiazine group demonstrated the lowest efficacy. In the surgical wound model, all groups achieved complete healing by day 21, with the 2% nano-formulation group exhibiting the fastest healing rate. However, histopathological evaluation performed on day 21 revealed that the silver sulfadiazine, mupirocin, and 5% Arnebia euchroma groups exhibited greater collagen density and more organised collagen fibre orientation, indicating superior tissue quality, whereas tissue in the 2% nano-formulation group appeared less mature.
Conclusion: The efficacy of wound treatment depends on the wound type. Both the nano-formulation and the herbal ointment demonstrated superior efficacy in the treatment of burn wounds. In surgical wounds, a trade-off was observed between the rate of healing and the quality of the regenerated tissue, suggesting that faster healing does not necessarily lead to superior tissue regeneration.
Keywords: Abukhalsa, Arnebia Euchroma, ointment, Mupirocin, silver nanoparticles, macroscopic, burn wound, surgical wound, wound healing
Type of Study: Brief Report |
Subject:
Reconstructive and Burn, Plastic surgery
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