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Background and purpose: Aerobic exercise has been recommended as an important strategy for management of cardiovascular diseases and endocrine-metabolic disorders. The aim of this study was to evaluate the effect of 6-weeks aerobic exercise training on oxidative stress and enzymatic antioxidants in postmenopausal women with hypertension. Materials and methods: In a quasi-experimental study, 20 sedentary postmenopausal women with hypertension (age: 50-55 years) with borderline to stage 1 hypertension at baseline were randomly divided in two groups: exercise training (ET, n = 10) and control (n = 10). Training program consisted of 45-60 minutes of aerobic exercise at 40-60 percent of maximal heart rate, 3 sessions per week for 6 weeks. The control group did not change their activity. Blood pressure measurements and blood samples were collected at baseline and after six weeks to evaluate levels superoxide dismutase (SOD), malondialdehyde (MDA) and catalase activity. Data were analyzed by paired and independent t tests. Results: Significant reduction in both systolic (P < 0.001) and diastolic (P = 0.008) blood pressure values was seen after exercise training which was accompanied by markedly increase of superoxide dismutase level (P = 0.004) and catalase activity (P = 0.001). Plasma malondialdehyde level was significantly reduced (P = 0.003) after exercise training. Conclusion: Six-weeks aerobic exercise was accompanied by significantly reduce resting systolic and diastolic blood pressure in postmenopausal women with hypertension this protective effect of exercise may be related to increased antioxidant defense and decreased oxidative damage resuted from regular aerobic exercise.

Keywords: Exercise, hypertension, menopause, stress oxidative

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