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Background and purpose: The epidemic of diabetes mellitus is one of the main concerns of the global health arena. This study investigated the effect of oral shoot “Crateagus‘s SPP” Branchlet on blood glucose, lipid profile, the level of oxidative stress in diabetic rats. Materials and methods: In this experimental study, we compared four groups of 15 teeth matched male rats: control, control treated with “Crataegus‘s SPP” Branchlet powder shoot, diabetic and diabetic treated with powder shoot. High blood glucose of 300 mg/dl and more was considered as an indicator of diabetes. Indicators of oxidative stress, including catalase, malonaldehyde, Superoxide Dismutase, glutathione peroxides and lipid parameters including triglycerides, total cholesterol, LDL, HDL, VLDL and also blood sugar and weight of rats were measured and reported using the mean and SD. Results: The statistical analysis of repeated measures analysis of variance showed that serum glucose, lipid profile (P<0.001) and the indicators of oxidative stress (PGPX, SOD, CAT, MDA< 0.001) were significantly affected with hawthorn. At significant level of 0.05, there is no difference between the treatment groups with control and diabetic groups for catalase. In diabetic rates, significant weight loss was achieved over time and compared with the control group (P<0.001). Conclusion: Based on our study, oral administration of “Crataegus‘s SPP” Branchlet in experimental diabetic male rats can improve blood sugar, lipids profile and oxidative stress disorders.

Keywords: Induced-diabetes, hyperlipidemia, hypoglycemia, oxidative stress, Crataegus

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