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Background and purpose: Candidal denture stomatitis is a common complication. The side effects and resistance to Candida against to nystatin have led researchers to look for other antifungal compounds. According to their recommendation, using grape vinegar and rose water can be a traditional mouthwash. The aim of the present study was to investigate the effect of this mouthwash on Candida in clinic and laboratory. Material and Methods: The clinical and laboratory investigation of 30 patients with grade 2 and 3 candidal denture stomatitis were randomly divided into two groups and treated with nystatin or traditional mouthwash. Clinically, the Candida colony counts in saliva samples before and after treatment were analyzed. Minimum inhibitory concentration and fungicidal concentration were obtained on Candida isolates. Results: Clinical symptoms improved in all patients with traditional mouthwash, while this rate was 69.23% for nystatin. All patients were satisfied in traditional mouthwash treatment, while3 9% of nystatin group were satisfied. Experimental results showed that both groups, the number of colonies of Candidaalbicans reduced in saliva. Most species of isolates was Candida albicans (81.81%). The MIC and MFC traditional mouthwash were 3.125 and 12.5 respectively Conclusion: Due to the efficacy and not having side effects in traditional mouthwash, and the patients’ complaints of the side effects of nystatin, traditional mouthwash grape vinegar and rose water can be administered as a pharmaceutical composition for the treatment of denture stomatitis candidiasis (Clinical Trials Registry Number: IRCT2013042713136N1)

Keywords: Denture stomatitis, Nystatin, Traditional mouth wash (vinegare+Rose water), Candida, MIC, MFC

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