Volume 22, Issue 1 (2-2013)                   J Mazandaran Univ Med Sci 2013, 22(1): 95-105 | Back to browse issues page

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Akbari J, Enayati-Fard R, Saeedi M, Morteza-Semnani K, mohammadian L. Effect of Temperature and Moisture on Physical properties and Release of Carbamazepine from the Polyethylene Glycol and Precirol Base. J Mazandaran Univ Med Sci 2013; 22 (1) :95-105
URL: http://jmums.mazums.ac.ir/article-1-3520-en.html
Effect of Temperature and Moisture on Physical properties and Release of Carbamazepine from the Polyethylene Glycol and Precirol Base
Jafar Akbari , Reza Enayati-Fard , Majid Saeedi , Katayoun Morteza-Semnani , Luqman mohammadian
Abstract:   (8378 Views)
Background and purpose: Solubility plays an important role in bioavailability of drugs. Any alter can cause changes in the physical and chemical properties of the drug release and consequently, changes in the bioavailability of the drug. It is necessary to recognize the best storage conditions to achieve desired drug release. Material and Methods: Carbamazepine tablets containing different ratios of polyethylene glycol and Precirol were prepared by direct compression method. The tablets were then placed in various temperatures and humidity for 6 months. Carbamazepine release was investigated from formulations and the data was processed with kinetic models. DSC and FTIR method was used to determine the physical stability of tablets. Results: The results of drug release from various formulations at zero time, 3 and 6 months showed significant differences in formulations containing PEG. The thermogram did not show any interaction between drug and excipients. Conclusion: Statistical studies of dissolution data revealed that storing carbamazepine tablets in different situations can cause significant changes in drug release profile. No changes were observed in the physical stability of the tablets.
Keywords: Carbamazepine, Precirol, PEG6000, SLS, release
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Type of Study: Research(Original) | Subject: Eye
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