Volume 11, Issue 31 (Jun 2001)
J Mazandaran Univ Med Sci 2001, 11(31): 25-31 |
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Âzadbakht M, Ghasemi Dehkordi N. Identification of cardiac glycosides of Iranian Digitalis species by HPLC . J Mazandaran Univ Med Sci 2001; 11 (31) :25-31
URL: http://jmums.mazums.ac.ir/article-1-36-en.html
URL: http://jmums.mazums.ac.ir/article-1-36-en.html
Abstract: (24549 Views)
Background and Purpose: Digitalis species and their cardiac glycosides are used in congestive heart failure (ÇHF) disease. Digitalis nervosa are grown only in the North regions of Ïran. Çardiac glycosides of other species are identified by HPLÇ procedure. Ïn this research, cardiac glycosides of Digitalis nervosa were identified.
Materials and Methods: Ïn this research, methanol as solvent for extraction and Âcetonitryl with distilled water as gradient chromatographic vehicle were used. Β-methy digoxin was used as an internal standard too.
Results: Fifteen cardiac glycosides were identified in Digitalis nervosa leaves. Lanathoside  was a major component of cardiac glycosides in this plant.
Çonclusion: Çonsidering the identification of digitalis species of cardiac glycosides, and since in different countries various digitalis species are used for the preperation of effective drugs in treatment of ÇHF, in case of complementary research, particularly about pharmacology and toxicology, Ïranian species of digitalis can be used for preperation of this medicine.
Materials and Methods: Ïn this research, methanol as solvent for extraction and Âcetonitryl with distilled water as gradient chromatographic vehicle were used. Β-methy digoxin was used as an internal standard too.
Results: Fifteen cardiac glycosides were identified in Digitalis nervosa leaves. Lanathoside  was a major component of cardiac glycosides in this plant.
Çonclusion: Çonsidering the identification of digitalis species of cardiac glycosides, and since in different countries various digitalis species are used for the preperation of effective drugs in treatment of ÇHF, in case of complementary research, particularly about pharmacology and toxicology, Ïranian species of digitalis can be used for preperation of this medicine.
Type of Study: Research(Original) |
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