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Background and purpose: Resveratrol (RSV) is a naturally existing polyphenolic compound abundantly found in grapes and several plants. It has potent free radical scavenger and antioxidative properties with significant effects in reducing oxidative damage. Oxidative stress and mitochondrial dysfunction contribute to PQ induced tissue damage. In this study, the protective effect of RSV was investigated against PQ induced mitochondrial toxicity in lung and brain isolated mitochondria. Material and Methods: Mitochondria were isolated from fresh rat’s lung and brain tissues using differential centrifugation technique. Isolated mitochondria were divided into control group, PQ group, and PQ plus RSV-pretreated group. Mitochondrial viability was assessed using the MTT colorimetric assay. Results: Paraquat induced mitochondrial dysfunction was found in lung and brain isolated mitochondria in a concentration-dependent manner and higher toxicity was observed in brain isolated mitochondria. RSV prevented PQ-induced mitochondrial dysfunction in rat’s lung and brain isolated mitochondria. Conclusion: Considering the protective effects of RSV against mitochondrial toxicity of PQ, this compound can be used as possible agent for prevention and treatment of pathological condition due to oxidative stress and mitochondrial dysfunction.

Keywords: Paraquat, resveratrol, mitochondrial dysfunction, brain, lung, MTT assay

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